Nodulisporic acids C, C1, and C2:: A series of D-ring-opened nodulisporic acids from the fungus Nodulisporium sp.

被引：19

作者：

Ondeyka, JG ^{[1
]}

Byrne, K ^{[1
]}

Vesey, D ^{[1
]}

Zink, DL ^{[1
]}

Shoop, WL ^{[1
]}

Goetz, MA ^{[1
]}

Singh, SB ^{[1
]}

机构：

[1] Merck Res Labs, Rahway, NJ 07065 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 01期

关键词：

D O I：

10.1021/np020339u

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Nodulisporic acids C (4a), C-1 (5a), and C-2 (6a), a series of D-ring-opened nodulisporic acids, were isolated from fermentations of a mutant culture of Nodulisporium sp. MF5954. Nodulisporic acid C, the most potent of the three, showed good activity against fleas with an LD90 of 10 mug/mL. These compounds tend to be unstable in the free acid form and were isolated as stable sodium salts.

引用

页码：121 / 124

页数：4

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