Distal Convoluted Tubule

被引：167

作者：

Subramanya, Arohan R. ^{[1
,2
,3
]}

Ellison, David H. ^{[4
,5
,6
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Sch Med, Dept Cell Biol, Pittsburgh, PA 15261 USA

[3] Vet Affairs Pittsburgh Healthcare Syst, Pittsburgh, PA USA

[4] Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97201 USA

[5] Oregon Hlth & Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97201 USA

[6] Portland VA Med Ctr, Portland, OR USA

来源：

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2014年 / 9卷 / 12期

基金：

美国国家卫生研究院;

关键词：

NA-CL COTRANSPORTER; SODIUM-CHLORIDE COTRANSPORTER; FAMILIAL HYPERKALEMIC HYPERTENSION; PSEUDOHYPOALDOSTERONISM TYPE-II; KELCH-LIKE; SENSORINEURAL DEAFNESS; MINERALOCORTICOID RECEPTOR; MOLECULAR PATHOGENESIS; BASOLATERAL MEMBRANE; POTASSIUM-TRANSPORT;

D O I：

10.2215/CJN.05920613

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The distal convoluted tubule is the nephron segment that lies immediately downstream of the macula densa. Although short in length, the distal convoluted tubule plays a critical role in sodium, potassium, and divalent cation homeostasis. Recent genetic and physiologic studies have greatly expanded our understanding of how the distal convoluted tubule regulates these processes at the molecular level. This article provides an update on the distal convoluted tubule, highlighting concepts and pathophysiology relevant to clinical practice.

引用

页码：2147 / 2163

页数：17