Distal Convoluted Tubule

被引：167
作者：
Subramanya, Arohan R. [1 ,2 ,3 ]
Ellison, David H. [4 ,5 ,6 ]
机构：
[1] Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15261 USA
[2] Univ Pittsburgh, Sch Med, Dept Cell Biol, Pittsburgh, PA 15261 USA
[3] Vet Affairs Pittsburgh Healthcare Syst, Pittsburgh, PA USA
[4] Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97201 USA
[5] Oregon Hlth & Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97201 USA
[6] Portland VA Med Ctr, Portland, OR USA
来源：
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2014年 / 9卷 / 12期
基金：
美国国家卫生研究院;
关键词：
NA-CL COTRANSPORTER; SODIUM-CHLORIDE COTRANSPORTER; FAMILIAL HYPERKALEMIC HYPERTENSION; PSEUDOHYPOALDOSTERONISM TYPE-II; KELCH-LIKE; SENSORINEURAL DEAFNESS; MINERALOCORTICOID RECEPTOR; MOLECULAR PATHOGENESIS; BASOLATERAL MEMBRANE; POTASSIUM-TRANSPORT;
D O I：
10.2215/CJN.05920613
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The distal convoluted tubule is the nephron segment that lies immediately downstream of the macula densa. Although short in length, the distal convoluted tubule plays a critical role in sodium, potassium, and divalent cation homeostasis. Recent genetic and physiologic studies have greatly expanded our understanding of how the distal convoluted tubule regulates these processes at the molecular level. This article provides an update on the distal convoluted tubule, highlighting concepts and pathophysiology relevant to clinical practice.
引用
收藏
页码：2147 / 2163
页数：17
相关论文
共 50 条
  • [31] Comparative transcriptomic analysis identifies evolutionarily conserved gene products in the vertebrate renal distal convoluted tubule
    Yuya Sugano
    Chiara Cianciolo Cosentino
    Dominique Loffing-Cueni
    Stephan C. F. Neuhauss
    Johannes Loffing
    Pflügers Archiv - European Journal of Physiology, 2017, 469 : 859 - 867
  • [32] Norepinephrine-Induced Stimulation of Kir4.1/Kir5.1 Is Required for the Activation of NaCl Transporter in Distal Convoluted Tubule
    Duan, Xin-Peng
    Gu, Li
    Xiao, Yu
    Gao, Zhong-Xiuzi
    Wu, Peng
    Zhang, Yun-Hong
    Meng, Xin-Xin
    Wang, Jun-Lin
    Zhang, Dan-Dan
    Lin, Dao-Hong
    Wang, Wen-Hui
    Gu, Ruimin
    HYPERTENSION, 2019, 73 (01) : 112 - 120
  • [33] Role of the distal convoluted tubule in renal Mg2+ handling: molecular lessons from inherited hypomagnesemia
    Ferre, Silvia
    Hoenderop, Joost J. G.
    Bindels, Rene J. M.
    MAGNESIUM RESEARCH, 2011, 24 (03) : S101 - S108
  • [34] Dietary sodium alters aldosterone's effect on renal sodium transporter expression and distal convoluted tubule remodelling
    Mutchler, Stephanie M.
    Hasan, Mahpara
    Murphy, Carolyn P.
    Baty, Catherine J.
    Boyd-Shiwarski, Cary
    Kirabo, Annet
    Kleyman, Thomas R.
    JOURNAL OF PHYSIOLOGY-LONDON, 2024, 602 (05): : 967 - 987
  • [35] Distal convoluted tubule-specific disruption of the COP9 signalosome but not its regulatory target cullin 3 causes tubular injury
    Maeoka, Yujiro
    Bradford, Tanner
    Su, Xiao-Tong
    Sharma, Avika
    Yang, Chao-Ling
    Ellison, David H.
    Mccormick, James A.
    Cornelius, Ryan J.
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2024, 327 (04) : F667 - F682
  • [36] Bradykinin Stimulates Renal Na+ and K+ Excretion by Inhibiting the K+ Channel (Kir4.1) in the Distal Convoluted Tubule
    Zhang, Dan-Dan
    Gao, Zhong-Xiuzi
    Vio, Carlos P.
    Xiao, Yu
    Wu, Peng
    Zhang, Hao
    Guo, Xi-Wen
    Meng, Xin-Xin
    Gu, Li
    Wang, Jun-Lin
    Duan, Xin-Peng
    Lin, Dao-Hong
    Wang, Wen-Hui
    Gu, Ruimin
    HYPERTENSION, 2018, 72 (02) : 361 - 369
  • [37] Specific disruption of calcineurin-signaling in the distal convoluted tubule impacts the transcriptome and proteome, and causes hypomagnesemia and metabolic acidosis
    Banki, Eszter
    Fisi, Viktoria
    Moser, Sandra
    Wengi, Agnieszka
    Carrel, Monique
    Loffing-Cueni, Dominique
    Penton, David
    V. Kratschmar, Denise
    Rizzo, Ludovica
    Lienkamp, Soeren
    Odermatt, Alex
    Rinschen, Markus M.
    Loffing, Johannes
    KIDNEY INTERNATIONAL, 2021, 100 (04) : 850 - 869
  • [38] Loss of sodium chloride co-transporter impairs the outgrowth of the renal distal convoluted tubule during renal development
    Schnoz, Christina
    Carrel, Monique
    Loffing, Johannes
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2020, 35 (03) : 422 - 432
  • [39] The Hydrogen-Coupled Oligopeptide Membrane Cotransporter Pept2 is SUMOylated in Kidney Distal Convoluted Tubule Cells
    Aroankins, Takwa S.
    Murali, Sathish K.
    Fenton, Robert A.
    Wu, Qi
    FRONTIERS IN MOLECULAR BIOSCIENCES, 2021, 8
  • [40] Regulation of distal tubule sodium transport: mechanisms and roles in homeostasis and pathophysiology
    Pearce, David
    Manis, Anna D.
    Nesterov, Viatcheslav
    Korbmacher, Christoph
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2022, 474 (08): : 869 - 884
12345