Tanshinone IIA Attenuates Bleomycin-Induced Pulmonary Fibrosis via Modulating Angiotensin-Converting Enzyme 2/Angiotensin-(1-7) Axis in Rats

被引：50
作者：
Wu, Huajie [1 ,3 ]
Li, Yan [4 ]
Wang, Yanxia [2 ,3 ]
Xu, Dunquan [2 ]
Li, Congcong [5 ]
Liu, Manling [2 ]
Sun, Xin [1 ]
Li, Zhichao [2 ,3 ]
机构：
[1] Fourth Mil Med Univ, Xijing Hosp, Dept Pediat, Xian 710032, Peoples R China
[2] Fourth Mil Med Univ, Dept Pathophysiol, Xian 710032, Peoples R China
[3] Fourth Mil Med Univ, Lung Injury & Repair Ctr, Xian 710032, Peoples R China
[4] Beijing Mil Gen Hosp, Med Examinat Ctr, Beijing, Peoples R China
[5] Fourth Mil Med Univ, Tangdu Hosp, Dept Resp Med, Xian 710032, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2014年 / 11卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Pulmonary fibrosis; transforming growth factor beta; Tanshinone IIA; angiotensin-converting enzyme 2; ANG-(1-7); LUNG FIBROSIS; TGF-BETA; CARDIAC FIBROBLASTS; EXPRESSION; INJURY; RECEPTOR; MICE; CARBOXYPEPTIDASE; HYPERTENSION; CONTRIBUTES;
D O I：
10.7150/ijms.8365
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pulmonary fibrosis (PF) is a common complication in those interstitial lung diseases patients, which will result in poor prognosis and short survival. Traditional therapeutic methods such as glucocorticoid and cytotoxic drugs are insufficient for treating PF and may cause severe side effects. Recent studies showed that traditional Chinese herbal abstraction such as Tanshinone IIA (TIIA) was displayed significant anti-PF effects in animal models. However, the exact mechanisms underlying the protective effects of TIIA were not fully understood. Here we further investigated the protective effects of TIIA and its mechanisms underlying. PF models of rat were induced by bleomycin (BLM); TIIA was administered subsequently. The PF changes were identified by histopathological analyses. The results showed that BLM resulted in severe PF and alveolar inflammation; together with significant elevation of transforming growth factor-beta 1 (TGF-beta 1). Angiotensin-converting enzyme 2 (ACE-2) together with angiotensin-(1-7) [ANG-(1-7)] were both greatly reduced after BLM administration. TIIA treatment notably attenuated BLM induced PF and inflammation, decreased expression of TGF-beta 1 and reversed ACE-2 and ANG-(1-7) production in rat lungs. Thus we may draw the conclusion that TIIA may exert protective effects on BLM induced PF in rats, and the ACE-2/ANG-(1-7) axis may ascribe to those protective effects.
引用
收藏
页码：578 / 586
页数：9
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