Airway remodeling in asthma: Therapeutic implications of mechanisms

被引：96
|
作者：
Homer, RJ [1 ]
Elias, JA
机构：
[1] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA
[2] Vet Aff Connecticut Healthcare Syst, Pathol & Lab Med Serv, West Haven, CT USA
[3] Yale Univ, Sch Med, Pulm & Crit Care Med Sect, New Haven, CT USA
来源：
PHYSIOLOGY | 2005年 / 20卷
关键词：
D O I：
10.1152/physiol.00035.2004
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Asthma is currently recognized as a chronic inflammatory disorder of the airways that leads to tissue injury and subsequent structural changes collectively called airway remodeling. Transgenic modeling of inflammatory mediators allows for the discovery of unexpected effects, dissection of downstream signaling events, and clues to future therapies.
引用
收藏
页码：28 / 35
页数：8
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