Identifying high-risk adult AML patients: epigenetic and genetic risk factors and their implications for therapy

被引：12

作者：

Bret, Caroline ^{[1
,2
,3
]}

Viziteu, Elena ^{[2
]}

Kassambara, Alboukadel ^{[1
,2
]}

Moreaux, Jerome ^{[1
,2
,3
]}

机构：

[1] CHU Montpellier, Dept Biol Hematol, F-34295 Montpellier 5, France

[2] CNRS, Inst Human Genet, UPR1142, F-34396 Montpellier, France

[3] Univ Montpellier I, UFR Med, Montpellier, France

来源：

EXPERT REVIEW OF HEMATOLOGY | 2016年 / 9卷 / 04期

关键词：

targeted treatment; Genetic; Acute myeloid Leukemia; Risk factors; Epigenetics; ACUTE MYELOID-LEUKEMIA; INTERNAL TANDEM DUPLICATION; ACUTE MYELOGENOUS LEUKEMIA; CHROMOSOMAL TRANSLOCATION FORMATION; HEMATOPOIETIC STEM; MONOSOMAL KARYOTYPE; DNA-DAMAGE; MICROSATELLITE INSTABILITY; GEMTUZUMAB OZOGAMICIN; PROGNOSTIC-SIGNIFICANCE;

D O I：

10.1586/17474086.2016.1141673

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute myeloid leukemia (AML) is a heterogeneous disease at molecular level, in response to therapy and prognosis. The molecular landscape of AML is evolving with new technologies revealing complex panorama of genetic abnormalities where genomic instability and aberrations of epigenetic regulators play a key role in pathogenesis. The characterization of AML diversity has led to development of new personalized therapeutic strategies to improve outcome of the patients.

引用

页码：351 / 360

页数：10

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