Cucurbit[8]uril-based supramolecular hydrogels for biomedical applications

被引：17
作者：
Wang, Zeyu [1 ]
Shui, Mingju [1 ]
Wyman, Ian W. [2 ]
Zhang, Qing-Wen [1 ]
Wang, Ruibing [1 ]
机构：
[1] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China
[2] Queens Univ, Dept Chem, Kingston, ON K7L 3N6, Canada
来源：
RSC MEDICINAL CHEMISTRY | 2021年 / 12卷 / 05期
基金：
中国国家自然科学基金;
关键词：
HOST-GUEST COMPLEXATION; KONJAC GLUCOMANNAN; CONTROLLED-RELEASE; DRUG-DELIVERY; DRIVING-FORCE; WATER; CUCURBITURILS; RECOGNITION; ASSEMBLIES; POLYMERS;
D O I：
10.1039/d1md00019e
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
As a member of the cucurbit[n]uril family (where n denotes the number of glycoluril units), cucurbit[8]uril (CB[8]) possesses a large cavity volume and is able to accommodate two guests simultaneously. Therefore, CB[8] has been adapted as a dynamic noncovalent crosslinker to form various supramolecular hydrogels. These CB[8]-based hydrogels have been investigated for various biomedical applications due to their good biocompatibility and dynamic properties afforded by host-guest interactions. In this review, we summarize the hydrogels that have been dynamically fabricated via supramolecular crosslinking of polymers by CB[8] reported during the past decade, and discuss their design principles, innovative applications in biomedical science and their future prospects.
引用
收藏
页码：722 / 729
页数：8
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