Synthesis of novel chlorophyll a derivatives bearing glucose moieties and estimation of their photocytotoxic activity

被引：0

作者：

Mal'shakova, M. V. ^{[1
]}

Rasova, E. E. ^{[2
]}

Velegzhaninov, I. O. ^{[2
]}

Belykh, D. V. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Chem, Fed Res Ctr Komi Sci Ctr, Ural Branch, 48 Pervomayskaya, Syktyvkar 167000, Russia

[2] Ural Branch Russian Acad Sci, Inst Biol, Fed Res Ctr Komi Sci Ctr, 28 Kommunisticheskaya, Syktyvkar 167982, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2022年 / 71卷 / 03期

关键词：

chlorophyll a; methyl pheophorbide a; pheophorbide a; pyropheophorbide a; D-glucose; 1,2:5,6-di-O-isopropylidene-D-glucofuranose; photocytotoxic activity; Mukaiyama reagent; PHOTODYNAMIC THERAPY; CHLORIN DERIVATIVES; NATURAL CHLORINS; D-GALACTOSE; PHOTOSENSITIZERS; PORPHYRINS; CYTOTOXICITY; DIAGNOSTICS; PERIPHERY; FRAGMENT;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of chlorophyll a derivatives bearing glucose moieties linked to the porphyrin macrocycle via ester bonds were synthesized. The dark cytotoxicity and photocytotoxicity of new chlorin-glucose conjugates were competitively evaluated in comparison with those of structurally similar chlorin-galactose derivatives synthesized previously. It was revealed that the introduction of the glucose moiety into the molecule of chlorophyll a derivative facilitates a decrease in the dark cytotoxicity relative to chlorin-galactose conjugates.

引用

页码：531 / 537

页数：7

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