Curcumin-loaded Fe-MOF/PDMS porous scaffold: Fabrication, characterization, and biocompatibility assessment

被引:26
作者
Nikpour, Soghra [1 ]
Ansari-Asl, Zeinab [1 ]
Sedaghat, Tahereh [1 ]
Hoveizi, Elham [2 ]
机构
[1] Shahid Chamran Univ Ahvaz, Fac Sci, Dept Chem, Ahvaz, Iran
[2] Shahid Chamran Univ Ahvaz, Fac Sci, Dept Biol, Ahvaz, Iran
关键词
Iron metal-organic framework; Polydimethylsiloxane; Curcumin; Composite; Sponge; Biocompatibility; Various natural polymers (collagen; hyaluronic acid; chitosan; METAL-ORGANIC FRAMEWORKS; TISSUE; COMPOSITES; ACID;
D O I
10.1016/j.jiec.2022.02.052
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Fabrication of biocompatible scaffolds that can facilitate the mending of damaged tissue has attracted much attention. In this study, the preparation and structural investigation of a curcumin-loaded Fe(II) metal-organic framework/polydimethylsiloxane sponge, Cur/Fe-MOF/PDMS, are reported. Various techniques such as FTIR (Fourier-transform infrared), XRD (X-ray diffraction), SEM (scanning electron microscope), TEM (transmission electron microscope), EDS (energy-dispersive X-ray spectroscopy) mapping, and XPS (X-ray photoelectron spectroscopy) have been used to investigate the as-fabricated materials. Results confirm the successful incorporation of curcumin and Fe-MOF into the PDMS matrix. The obtained SEM images indicate the sponge-like structures of the PDMS and the Fe-MOF/PDMS composite. Indeed, the results from in vivo show animals all to be survived without any unusual responses to the transplant. According to macroscopic observation, the Fe-MOF/PDMS and Cur/Fe-MOF/PDMS scaffolds seem better confederates than the pure PDMS. H&E staining has confirmed enhanced healing and revascularization in the Cur/Fe-MOF/PDMS than the PDMS and Fe-MOF/PDMS scaffolds. Additionally, a twostage profile was observed for the release of curcumin into PBS (phosphate-buffered saline) solution. The hydrophilic property of the Fe-MOF resulted in fast release at the first stage. These results exhibit that the Cur/Fe-MOF/PDMS sponge can serve as a 3D porous substrate in the tissue engineering (TE) field.(c) 2022 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:188 / 197
页数:10
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共 70 条
  • [1] Improving pharmacologically relevant properties of sulfasalazine loaded in y-cyclodextrin-based metal organic framework
    Agafonov, Mikhail
    Garibyan, Anna
    Terekhova, Irina
    [J]. JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 2022, 106 : 189 - 197
  • [2] Properties of multifunctional composite materials based on nanomaterials: a review
    Ali, Alamry
    Andriyana, Andri
    [J]. RSC ADVANCES, 2020, 10 (28) : 16390 - 16403
  • [3] Mechanical properties of short flax fibre bundle/polypropylene composites:: Influence of matrix/fibre modification, fibre content, water uptake and recycling
    Arbelaiz, A
    Fernández, B
    Ramos, JA
    Retegi, A
    Llano-Ponte, R
    Mondragon, I
    [J]. COMPOSITES SCIENCE AND TECHNOLOGY, 2005, 65 (10) : 1582 - 1592
  • [4] Natural biomacromolecule based composite scaffolds from silk fibroin, gelatin and chitosan toward tissue engineering applications
    Asadpour, Shiva
    Kargozar, Saeid
    Moradi, Lida
    Ai, Armin
    Nosrati, Hamed
    Ai, Jafar
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 154 : 1285 - 1294
  • [5] Controlled Curcumin Release from Hydrogel Scaffold Platform Based on 2-Hydroxyethyl Methacrylate/Gelatin/Alginate/Iron(III) Oxide
    Babic, Marija M.
    Vukomanovic, Marija
    Stefanic, Martin
    Nikodinovic-Runic, Jasmina
    Tomic, Simonida Lj.
    [J]. MACROMOLECULAR CHEMISTRY AND PHYSICS, 2020, 221 (20)
  • [6] Morphological and optical properties of porous hydroxyapatite/cornstarch (HAp/Cs) composites
    Beh, C. Y.
    Cheng, E. M.
    Nasir, N. F. Mohd
    Tarmizi, Emma Ziezie Mohd
    Eng, S. K.
    Majid, M. S. Abdul
    Ridzuan, M. J. M.
    Khor, S. F.
    Saad, F. S. Ahmad
    [J]. JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T, 2020, 9 (06): : 14267 - 14282
  • [7] Additive manufacturing of natural biopolymers and composites for bone tissue engineering
    Bose, Susmita
    Koski, Caitlin
    Vu, Ashley A.
    [J]. MATERIALS HORIZONS, 2020, 7 (08) : 2011 - 2027
  • [8] 3D printing of PCL/nano-hydroxyapatite scaffolds derived from biogenic sources for bone tissue engineering
    Cestari, Francesca
    Petretta, Mauro
    Yang, Yuejiao
    Motta, Antonella
    Grigolo, Brunella
    Sglavo, Vincenzo M.
    [J]. SUSTAINABLE MATERIALS AND TECHNOLOGIES, 2021, 29
  • [9] 3D printed carboxymethyl cellulose scaffolds for autologous growth factors delivery in wound healing
    Diaz-Gomez, Luis
    Gonzalez-Prada, Iago
    Millan, Rosendo
    Da Silva-Candal, Andres
    Bugallo-Casal, Ana
    Campos, Francisco
    Concheiro, Angel
    Alvarez-Lorenzo, Carmen
    [J]. CARBOHYDRATE POLYMERS, 2022, 278
  • [10] Quantitative evaluation of the in vivo biocompatibility and performance of freeze-cast tissue scaffolds
    Divakar, Prajan
    Moodie, Karen L.
    Demidenko, Eugene
    Hoopes, P. Jack
    Wegst, Ulrike G. K.
    [J]. BIOMEDICAL MATERIALS, 2020, 15 (05)