Resolution of allergic asthma

被引：44

作者：

Finotto, Susetta ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Mol Pneumol, Kussmaul Campus Med Res,Hartmannstr 14, D-91054 Erlangen, Germany

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2019年 / 41卷 / 06期

关键词：

Allergic asthma; Resolution of inflammation; Airways; Epithelium; Lymphocytes; Eosinophils; FACTOR T-BET; TRANSCRIPTION FACTOR; TH9; CELLS; IMMUNE-RESPONSES; AIRWAY INFLAMMATION; IL-9; EXPRESSION; TGF-BETA; NEUTROPHILS; DIFFERENTIATION; RECEPTOR;

D O I：

10.1007/s00281-019-00770-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Allergic asthma is an inflammatory disease of the airways characterized by recurrent episodes of wheezing and bronchoconstriction. Chronic inflammation may finally lead to structural damage followed by airway remodeling. Various studies in recent years contributed to unravel important aspects of the immunopathogenesis of asthma and adapted new pharmaceutical developments. Here, I consider some novel insights into the immunopathogenesis of asthma and the protective and pathogenic roles of some innate and adaptive immune cells as well as the function of soluble mediators such as cytokines. Particular attention will be given to new concepts on resolution of chronic airway inflammation for prevention of airway structural damage.

引用

页码：665 / 674

页数：10

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