Overcoming Immune Resistance With Radiation Therapy in Prostate Cancer

被引：14

作者：

Mulvey, Arthur ^{[1
,2
]}

Muggeo-Bertin, Emilien ^{[3
]}

Berthold, Dominik R. ^{[1
]}

Herrera, Fernanda G. ^{[2
,3
,4
]}

机构：

[1] Lausanne Univ Hosp, Dept Oncol, Med Oncol Serv, Lausanne, Switzerland

[2] Lausanne Univ Hosp, Dept Oncol, Immunooncol Serv, Lausanne, Switzerland

[3] Lausanne Univ Hosp, Dept Oncol, Radiat Oncol Serv, Lausanne, Switzerland

[4] Ludwig Inst Canc Res, Lausanne Branch, Lausanne, Switzerland

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

prostate cancer; radiation therapy; immunotherapy; immune checkpoint inhibitors; tumor micro-environment; cold tumor; abscopal effect; LOW-DOSE IRRADIATION; REGULATORY T-CELLS; PHASE-III TRIAL; MHC CLASS-I; IONIZING-RADIATION; DOUBLE-BLIND; DOCETAXEL CHEMOTHERAPY; METASTATIC MELANOMA; TUMOR ANGIOGENESIS; GAMMA-IRRADIATION;

D O I：

10.3389/fimmu.2022.859785

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Prostate cancer is the second most common cancer in men and represents a significant healthcare burden worldwide. Therapeutic options in the metastatic castration-resistant setting remain limited, despite advances in androgen deprivation therapy, precision medicine and targeted therapies. In this review, we summarize the role of immunotherapy in prostate cancer and offer perspectives on opportunities for future development, based on current knowledge of the immunosuppressive tumor microenvironment. Furthermore, we discuss the potential for synergistic therapeutic strategies with modern radiotherapy, through modulation of the tumor microenvironment. Emerging clinical and pre-clinical data suggest that radiation can convert immune desert tumors into an inflamed immunological hub, potentially sensitive to immunotherapy.

引用

页数：16

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