ONE-STEP IMMUNOASSAYS USING INTEGRATED NANOROD ARRAYS FOR RAPID AND SENSITIVE DETECTION OF CANCER BIOMARKERS

被引：0
|
作者：
Ye, Yuxin [1 ]
Yang, Fan [1 ]
Cao, Zhen [1 ]
机构：
[1] Zhejiang Univ, Coll Informat Sci & Elect Engn, Hangzhou 310027, Peoples R China
来源：
2022 IEEE 35TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS CONFERENCE (MEMS) | 2022年
基金：
中国国家自然科学基金;
关键词：
Nanorods; Plasmonics; Immunoassay; Oblique angle deposition;
D O I：
10.1109/MEMS51670.2022.9699794
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
We report the integration of Au nanorod arrays with microfluidic chips for rapid and sensitive one-step immunoassays. The nanorods are fabricated through an easy physical deposition method called oblique angle deposition (OAD) without resorting to advanced lithography tools. Leveraging on this platform, we demonstrate detection of cancer biomarkers including prostate-specific antigen (PSA) and carcinoembryonic antigen (CEA) with improved sensitivity and shortened assay time. The detection limit of PSA and CEA can reach down to 2.9 pg/mL (similar to 0.1 pM) and 131.4 pg/mL (similar to 1.8 pM), respectively, which corresponds to an enhancement of 1000 and 400 times compared with conventional glass substrates. With high assay performance and simple manufacturing process, this platform has great potentials in application of point-of-care diagnosis.
引用
收藏
页码：919 / 922
页数：4
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