DNA microarray gene expression analysis of human vascular endothelial cells exposed to arsenite

被引：4
|
作者：
Fujiwara, Yasuyuki [1 ]
Honda, Akiko [1 ]
Satoh, Masahiko [1 ]
机构：
[1] Aichi Gakuin Univ, Sch Pharm, Lab Pharmaceut Hlth Sci, Chikusa Ku, Aichi 4648650, Japan
来源：
JOURNAL OF TOXICOLOGICAL SCIENCES | 2010年 / 35卷 / 02期
关键词：
Arsenite; DNA microarray; Human vascular endothelial cell; Atherosclerosis;
D O I：
10.2131/jts.35.275
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
DNA microarray was used to monitor the transcriptional response of human brain microvascular endothelial cells (HBMEC) and human coronary artery endothelial cells (HCAEC) to sodium arsenite (iAs(III)). iAs(III) enhanced the expression of 10 and 6 genes, and reduced the expression of 45 and 20 genes in HBMEC and HCAEC, respectively. Among the 64 genes whose expression was changed in some way, HBMEC and HCAEC had 5 up-regulated and 12 down-regulated genes in common.
引用
收藏
页码：275 / 278
页数：4
相关论文
共 50 条
  • [21] DNA microarray analysis of gene expression in human optic nerve head astrocytes in response to hydrostatic pressure
    Yang, P
    Agapova, O
    Parker, A
    Shannon, W
    Pecen, P
    Duncan, J
    Salvador-Silva, M
    Hernandez, MR
    PHYSIOLOGICAL GENOMICS, 2004, 17 (02) : 157 - 169
  • [22] NADH oxidase activation is involved in arsenite-induced oxidative DNA damage in human vascular smooth muscle cells
    Lynn, S
    Gurr, JR
    Lai, HT
    Jan, KY
    CIRCULATION RESEARCH, 2000, 86 (05) : 514 - 519
  • [23] Microarray analysis of bisphenol A-induced changes in gene expression in human oral epithelial cells
    Seki, Keisuke
    Koshi, Ryosuke
    Sugano, Naoyuki
    Masutani, Shigeyuki
    Yoshinuma, Naoto
    Ito, Koichi
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2007, 39 (11) : 879 - 884
  • [24] Gene expression in the vascular wall of the aortic arch in spontaneously hypertensive hyperlipidemic model rats using DNA microarray analysis
    Koizumi, Go
    Kumai, Toshio
    Egawa, Shunya
    Yatomi, Kentaro
    Hayashi, Takeshi
    Oda, Go
    Ohba, Keiichiro
    Iwai, Shinichi
    Watanabe, Minoru
    Matsumoto, Naoki
    Oguchi, Katsuji
    LIFE SCIENCES, 2013, 93 (15) : 495 - 502
  • [25] Gene expression profiling by DNA microarray technology
    Iida, K
    Nishimura, I
    CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE, 2002, 13 (01) : 35 - 50
  • [26] Gene Expression Profiles by Microarray Analysis during Matrigel-induced Tube Formation in a Human Extravillous Trophoblast Cell line: Comparison with Endothelial Cells
    Fukushima, K.
    Murata, M.
    Hachisuga, M.
    Tsukimori, K.
    Seki, H.
    Takeda, S.
    Kato, K.
    Wake, N.
    PLACENTA, 2008, 29 (10) : 898 - 904
  • [27] Inflammatory gene expression patterns revealed by DNA microarray analysis in TNF-α-treated SGBS human adipocytes
    Do, Myoung-Sool
    Jeong, Hun-Soon
    Choi, Bong-Hyuk
    Hunter, Leif
    Langley, Stuart
    Pazmany, Laszlo
    Trayhurn, Paul
    YONSEI MEDICAL JOURNAL, 2006, 47 (05) : 729 - 736
  • [28] Monitoring the gene expression profiles of doxorubicin-resistant acute myelocytic leukemia cells by DNA microarray analysis
    Song, Ju Han
    Choi, Cheol Hee
    Yeom, Hye-Jung
    Hwang, Seung Yong
    Kim, Tae Sung
    LIFE SCIENCES, 2006, 79 (02) : 193 - 202
  • [29] Differential gene expression profiling of human umbilical cord blood-derived mesenchymal stem cells by DNA microarray
    Jeong, JA
    Hong, SH
    Gang, EJ
    Ahn, C
    Hwang, SH
    Yang, IH
    Han, H
    Kim, H
    STEM CELLS, 2005, 23 (04) : 584 - 593
  • [30] Bismuth protects against arsenite-induced inhibition of proteoglycan synthesis in cultured vascular endothelial cells
    Fujiwara, Yasuyuki
    Yamamoto, Chika
    Inagaki, Takayuki
    Satoh, Masahiko
    Kaji, Toshiyuki
    JOURNAL OF TOXICOLOGICAL SCIENCES, 2012, 37 (04) : 837 - 843
12345