Lectins as mitosis stimulating factors: Briefly reviewed

被引：35
作者：
Carvalho, Elba V. M. M. [1 ]
Oliveira, Weslley F. [1 ]
Coelho, Luana C. B. B. [1 ]
Correia, Maria T. S. [1 ]
机构：
[1] Univ Fed Pernambuco UFPE, Dept Bioquim, Ctr Biociencias, Av Prof Moraes Rego S-N,Cidade Univ, BR-50670420 Recife, PE, Brazil
来源：
LIFE SCIENCES | 2018年 / 207卷
关键词：
Lectin; Lymphocyte; Cell proliferation; Mitosis; CELL-PROLIFERATION; LYMPHOCYTE-PROLIFERATION; CYTOKINE PRODUCTION; MITOGENIC RESPONSE; T-CELLS; PROTEIN; DNA; PURIFICATION; EXPRESSION; PATHWAY;
D O I：
10.1016/j.lfs.2018.06.003
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Lectins are carbohydrate binding proteins that can stimulate cell proliferation. This property makes these bio-molecules capable of being used as mitogen reagents to study the interaction with lymphocytes allowing evaluation of immunomodulatory action, since B and T lymphocytes are related to humoral and innate immunity, respectively. Isolated cells from spleen, which include lymphocytes, are widely applied as a model in screening lectin mitogenic capacity. This mitotic stimulus is initiated by interaction of the lectin with T-cell receptor on cell surface. This brief review article aims to explain how cell proliferation, especially lymphocytes, can be achieved through lectin induction. Additionally, this work intends to highlight the main colorimetric and radiographic techniques to encourage the scientific community in searching for new mitogenic lectins.
引用
收藏
页码：152 / 157
页数：6
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