Bisphenol A as degradation product of monomers used in resin-based dental materials

被引：38

作者：

De Nys, Siemon ^{[1
,2
]}

Duca, Radu Corneliu ^{[3
,4
]}

Vervliet, Philippe ^{[5
]}

Covaci, Adrian ^{[5
]}

Boonen, Imke ^{[6
]}

Elskens, Marc ^{[6
]}

Vanoirbeek, Jeroen ^{[3
]}

Godderis, Lode ^{[3
,7
]}

Van Meerbeek, Bart ^{[1
,2
]}

Van Landuyt, Kirsten L. ^{[1
,2
]}

机构：

[1] KU Leuven Univ Leuven, BIOMAT, Dept Oral Hlth Sci, Kapucijnenvoer 7 Block A,Box 7001, B-3000 Leuven, Belgium

[2] Univ Hosp Leuven UZ Leuven, Leuven, Belgium

[3] Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, Environm & Hlth, Kapucijnenvoer 35, B-3000 Leuven, Belgium

[4] Natl Hlth Lab LNS, Unit Environm Hyg & Human Biol Monitoring, Dept Hlth Protect, L-3555 Dudelange, Luxembourg

[5] Univ Antwerp, Toxicol Ctr, Univ Pl 1,DS 551, B-2610 Antwerp, Belgium

[6] Vrije Univ Brussel, Lab Analyt Environm & Geochem, Pl Laan 2, B-1050 Ixelles, Belgium

[7] IDEWE, External Serv Prevent & Protect Work, B-3001 Heverlee, Belgium

来源：

DENTAL MATERIALS | 2021年 / 37卷 / 06期

基金：

比利时弗兰德研究基金会;

关键词：

Bisphenol A; Dental monomer; Impurity; Degradation; BULK-FILL; COMPOSITES; ESTROGENICITY; SEALANTS; SALIVA;

D O I：

10.1016/j.dental.2021.03.005

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objective. There is still much debate about the release of bisphenol-A (BPA) from dental materials. Therefore, this study aimed to quantify BPA present as an impurity in both BPA-based and non-BPA-based monomers and to evaluate whether these monomers may degrade to BPA upon salivary, bacterial, and chemical challenges. Methods. BPA was determined in three different amounts (1, 2, and 3 mu mol) of each monomer (TEGDMA, UDMA, mUDMA, BisGMA, BisEMA-3, -6, -10, -30, BisPMA, EBPADMA urethane, BADGE, and BisDMA). Next, the monomers (3 similar to mol) were immersed in whole human pooled saliva collected from adults, Streptococcus mutans (2 x 10(7) CFU/mL), and acidic (0.1 M HCl), alkaline (0.1 M NaOH), and control media. The amount of BPA was quantified using a specific and highly sensitive UPLC-MS/MS method including derivatization of BPA by pyridine-3-sulfonyl chloride. Results. The monomers BisGMA and BisEMA-3 contained trace amounts (0.0006% and 0.0025%, respectively) of BPA as impurities of their synthesis process. BPA concentrations increased when the monomers BisGMA, BisEMA-3, BisEMA-6, BisEMA-10, BisPMA and BADGE were exposed to saliva and S. mutans, indicating degradation of a small amount of monomer into BPA. In addition, BisPMA and BADGE degraded into BPA under alkaline conditions. The conversion rate of the monomers into BPA ranged between 0.0003% and 0.0025%. Significance. Impurities and degradation of BPA-based monomers may account for the release of BPA from resin-based dental materials. Even though the detected amounts of BPA due to monomer impurity were small, manufacturers of dental materials can reduce the BPA content by using only monomers of the highest purity. Considering the overall current trend towards BPA-free materials, it may be recommendable to investigate whether non-BPA based monomers can be used in dental resin-based materials. (C) 2021 The Academy of Dental Materials. Published by Elsevier Inc. All rights reserved.

引用

页码：1020 / 1029

页数：10

共 35 条

[1] Qualitative and quantitative characterization of monomers of uncured bulk-fill and conventional resin-composites using liquid chromatography/mass spectrometry [J].