The structures of premithramycinone and demethylpremithramycinone, plausible early intermediates of the aureolic acid group antibiotic mithramycin

被引：31

作者：

Rohr, J

Weissbach, U

Beninga, C

Künzel, E

Siems, K

Bindseil, KU

Lombó, F

Prado, L

Braña, AF

Méndez, C

Salas, JA

机构：

[1] Univ Gottingen, Inst Organ Chem, D-37077 Gottingen, Germany

[2] AnalytiCon AG, Bereich Wirkstoffe, D-14473 Potsdam, Germany

[3] Univ Oviedo, Dept Biol Func, E-33006 Oviedo, Spain

[4] Univ Oviedo, Inst Biotecnol Asturias, E-33006 Oviedo, Spain

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 03期

关键词：

D O I：

10.1039/a707446h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The structures of premithramycinone and its demethyl analogue suggest that the aureolic acid antibiotics are biosynthetically formed via a tetracycline-type, and not a tetracenomycin-type, folded decaketide.

引用

页码：437 / 438

页数：2

共 6 条

[1] The novel hybrid antitumor compound premithramycinone H provides indirect evidence for a tricyclic intermediate of the biosynthesis of the aureolic acid antibiotic mithramycin
Lombó, F
Künzel, E
Prado-Alvarez, L
Braña, AF
Bindseil, KU
Frevert, J
Bearden, D
Méndez, C
Salas, JA
Rohr, J
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2000, 39 (04) : 796 - 799
[2] The novel hybrid antitumor compound premithramycinone H provides indirect evidence for a tricyclic intermediate of the biosynthesis of the aureolic acid antibiotic mithramycin
Lombo, Felipe
Kunzel, Eva
Prado, Laura
Brana, Alfredo F.
Bindseil, Kai U.
Frevert, Jurgen
Bearden, Dan
Mendez, Carmen
Salas, Jose A.
Rohr, Jurgen
Angewandte Chemie (International Edition in English), 2000, 39 (04): : 796 - 799
[3] Olivomycin A - an Antitumor Antibiotic of the Aureolic Acid Group (Review)
Tevyashova, A. N.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2016, 50 (07) : 425 - 430
[4] Olivomycin A – an Antitumor Antibiotic of the Aureolic Acid Group (Review)
A. N. Tevyashova
Pharmaceutical Chemistry Journal, 2016, 50 : 425 - 430
[5] STRUCTURAL STUDIES OF INTERMEDIATES IN ANTIBIOTIC-SYNTHESIS .2. THE STRUCTURES OF METHOXYIMINOMALONIC ACID AND ITS METHYL AND BENZHYDRYL MONOESTERS
HARAN, TE
NUDELMAN, A
SHAKKED, Z
ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1983, 39 (AUG): : 438 - 444
[6] STRUCTURAL STUDIES OF INTERMEDIATES IN ANTIBIOTIC-SYNTHESIS .1. THE STRUCTURES OF PENICILLIN SULFOXIDE REARRANGEMENT PRODUCTS - 2,3,5,6-TETRAHYDRO-5-HYDROXYMETHYL-6,6-DIMETHYL-1,3-DIOXO-8-[(PHENYLACETYL)AMINO]-1H-IMIDAZO[5,1-C][1,4]THIAZINE (I), C17H19N3O4S, AND 2,3,5,6-TETRAHYDRO-6,6-DIMETHYL-1,3-DIOXO-8-[(PHENYLACETYL)AMINO]-1H-IMIDAZO[5,1-C]-[1,4]THIAZINE-5-CARBOXYLIC ACID (II), C17H17N3O5SC]
HARAN, TE
NUDELMAN, A
SHAKKED, Z
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1983, 39 (JUL) : 882 - 887

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