Extracellular vesicles in neuroinflammation: Pathogenesis, diagnosis, and therapy

被引：41

作者：

Ruan, Jing ^{[1
]}

Miao, Xiaomin ^{[2
]}

Schlueter, Dirk ^{[3
,4
]}

Lin, Li ^{[2
]}

Wang, Xu ^{[2
,3
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Pathol, Wenzhou 325000, Peoples R China

[2] Wenzhou Med Univ, Sch Pharmaceut Sci, Chashan High Educ Pk, Wenzhou 325035, Peoples R China

[3] Hannover Med Sch, Inst Med Microbiol & Hosp Epidemiol, D-30625 Hannover, Germany

[4] Hannover Med Sch, Cluster Excellence RESIST EXC 2155, D-30625 Hannover, Germany

来源：

MOLECULAR THERAPY | 2021年 / 29卷 / 06期

基金：

中国国家自然科学基金;

关键词：

TRAUMATIC BRAIN-INJURY; ASTROCYTE-DERIVED EXOSOMES; SPINAL-CORD-INJURY; FUNCTIONAL RECOVERY; MULTIPLE-SCLEROSIS; MYELOID MICROVESICLES; CEREBROSPINAL-FLUID; ALPHA-SYNUCLEIN; AMYLOID-BETA; MOUSE MODEL;

D O I：

10.1016/j.ymthe.2021.04.020

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Extracellular vesicles (EVs) are bilayer membrane vesicles and act as key messengers in intercellular communication. EVs can be secreted by both neurons and glial cells in the central nervous system (CNS). Under physiological conditions, EVs contribute to CNS homeostasis by facilitating omnidirectional communication among CNS cell populations. In response to CNS injury, EVs mediate neuroinflammatory responses and regulate tissue damage and repair, thereby influencing the pathogenesis, development, and/or recovery of neuroinflammatory diseases, including CNS autoimmune diseases, neurodegenerative diseases, stroke, CNS traumatic injury, and CNS infectious diseases. The unique ability of EVs to pass through the blood-brain barrier further confers them an important role in the bidirectional communication between the CNS and periphery, and application of EVs enables the diagnosis, prognosis, and therapy of neuroinflammatory diseases in a minimally invasive manner.

引用

页码：1946 / 1957

页数：12

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