Highly Efficient One-Pot Synthesis of 2-Substituted Quinazolines and 4H-Benzo[d][1,3]oxazines via Cross Dehydrogenative Coupling using Sodium Hypochlorite

被引:125
作者
Maheswari, C. Uma [1 ]
Kumar, G. Sathish [1 ]
Venkateshwar, M. [1 ]
Kumar, R. Arun [1 ]
Kantam, M. Lakshmi [1 ]
Reddy, K. Rajender [1 ]
机构
[1] Indian Inst Chem Technol, Inorgan & Phys Chem Div, Hyderabad 500607, Andhra Pradesh, India
关键词
2-aryl-4H-benzo[d][1,3]oxazines; dehydrogenation; oxidation; quinazolines; sodium hypochlorite; TYROSINE KINASE INHIBITORS; DERIVATIVES; RECEPTOR; ALDEHYDES; AMINES; 4-ANILINOQUINAZOLINES; 2-ARYLBENZOXAZOLES; DISCOVERY; OXIDATION; QUINOLINE;
D O I
10.1002/adsc.200900715
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
This communication describes a catalyst-free synthesis of 2-substituted quinazolines and 4H-benzo[d][1,3]oxazines using commericially available sodium hypochlorite as oxidant. Operational simplicity, mild reaction conditions and the ability to construct structurally diverse 2-quinazolines and 2-substituted 4H-benzo[d][1,3]oxazines by this method render it to be a practical alternative for the synthesis of these heterocycles.
引用
收藏
页码:341 / 346
页数:6
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