Functional and neurochemical interactions within the amygdala-medial prefrontal cortex circuit and their relevance to emotional processing

被引：51

作者：

Delli Pizzi, Stefano ^{[1
,2
,3
]}

Chiacchiaretta, Piero ^{[1
,2
]}

Mantini, Dante ^{[4
,5
,6
]}

Bubbico, Giovanna ^{[1
,2
]}

Ferretti, Antonio ^{[1
,2
]}

Edden, Richard A. ^{[7
,8
]}

Di Giulio, Camillo ^{[1
]}

Onofrj, Marco ^{[1
,3
]}

Bonanni, Laura ^{[1
,3
]}

机构：

[1] G dAnnunzio Univ Chieti Pescara, Dept Neurosci Imaging & Clin Sci, Chieti, Italy

[2] G dAnnunzio Univ Chieti Pescara, Inst Adv Biomed Technol ITAB, Chieti, Italy

[3] G dAnnunzio Univ Chieti Pescara, Aging Res Ctr, Chieti, Italy

[4] Katholieke Univ Leuven, Res Ctr Motor Control & Neuroplast, Louvain, Belgium

[5] Swiss Fed Inst Technol, Neural Control Movement Lab, Dept Hlth Sci & Technol, Zurich, Switzerland

[6] Univ Oxford, Dept Expt Psychol, Oxford, England

[7] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD USA

[8] Kennedy Krieger Inst, FM Kirby Ctr Funct MRI, Baltimore, MD USA

来源：

BRAIN STRUCTURE & FUNCTION | 2017年 / 222卷 / 03期

关键词：

Amygdala; gamma-Aminobutyric acid (GABA); Trait anxiety; Medial prefrontal cortex (mPFC); SOCIAL ANXIETY DISORDER; GAMMA-AMINOBUTYRIC-ACID; BASOLATERAL AMYGDALA; NORMATIVE VALUES; RECEPTOR ARCHITECTURE; ORBITOFRONTAL CORTEX; NEGATIVE AFFECT; BRAIN NETWORKS; CONNECTIVITY; GABA;

D O I：

10.1007/s00429-016-1276-z

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The amygdala-medial prefrontal cortex (mPFC) circuit plays a key role in emotional processing. GABA-ergic inhibition within the mPFC has been suggested to play a role in the shaping of amygdala activity. However, the functional and neurochemical interactions within the amygdala-mPFC circuits and their relevance to emotional processing remain unclear. To investigate this circuit, we obtained resting-state functional magnetic resonance imaging (rs-fMRI) and proton MR spectroscopy in 21 healthy subjects to assess the potential relationship between GABA levels within mPFC and the amygdala-mPFC functional connectivity. Trait anxiety was assessed using the State-Trait Anxiety Inventory (STAI-Y2). Partial correlations were used to measure the relationships among the functional connectivity outcomes, mPFC GABA levels and STAI-Y2 scores. Age, educational level and amount of the gray and white matters within H-1-MRS volume of interest were included as nuisance variables. The rs-fMRI signals of the amygdala and the vmPFC were significantly anti-correlated. This negative functional coupling between the two regions was inversely correlated with the GABA+/tCr level within the mPFC and the STAI-Y2 scores. We suggest a close relationship between mPFC GABA levels and functional interactions within the amygdala-vmPFC circuit, providing new insights in the physiology of emotion.

引用

页码：1267 / 1279

页数：13

共 94 条

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