Overexpression of Hexokinase 1 as a poor prognosticator in human colorectal cancer

被引：29
作者：
He, Xiaosheng [1 ,2 ]
Lin, Xutao [1 ,2 ]
Cai, Muyan [3 ,4 ]
Zheng, Xiaobin [1 ,2 ]
Lian, Lei [1 ,2 ]
Fan, Dejun [1 ,2 ]
Wu, Xiaojian [1 ,2 ]
Lan, Ping [1 ,2 ]
Wang, Jianping [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Dept Colorectal Surg, Affiliated Hosp 6, Guangzhou 510655, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Guangdong Prov Key Lab Colorectal & Pelv Floor Di, Affiliated Hosp 6, 26 Yuancun Er Heng Rd, Guangzhou 510655, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Ctr Canc, Guangzhou 510060, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Ctr Canc, Dept Pathol, Guangzhou 510060, Guangdong, Peoples R China
来源：
TUMOR BIOLOGY | 2016年 / 37卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Colorectal cancer; Hexokinase; Prognosis; Biomarker; DEPENDENT ANION CHANNELS; EXPRESSION; METABOLISM; PATHWAY; GLYCOLYSIS; SURVIVAL; ENZYMES; PROFILE; GENES; CELLS;
D O I：
10.1007/s13277-015-4255-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
It has been suggested that hexokinase 1 (HK1) is involved in tumorigenesis. However, the expression dynamics of HK1 and its prognostic significance in human colorectal cancer (CRC) still remain unclear. The aim of the present study was to investigate the expression of HK1 and its prognostic significance in CRC. In this study, immunohistochemical analysis was used to examine the expression dynamics of HK1 in CRC tissues from two independent cohorts. Receiver operating characteristic curve analysis, Kaplan-Meier curves, and Cox regression analysis were utilized to investigate the prognostic significance. Results showed that a high expression of HK1 was observed in 106 of 393 (27.0 %) and 69 of 229 (30.1 %) of CRC in the training cohort and validation cohort, respectively. Further correlation analyses indicated that the increased HK1 expression was strongly correlated with the pN classification and TNM stage. Both cohorts showed a close association between the overexpression of HK1 and poorer overall survival. Importantly, multivariate analysis identified HK1 expression in CRC as an independent prognostic factor. Overexpression of HK1 may act as a significant biomarker of poor prognosis for patients with CRC.
引用
收藏
页码：3887 / 3895
页数：9
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