IN VITRO STUDY OF ANTIOXIDANT AND SCAVENGER PROPERTIES OF PHENOLIC COMPOUNDS FROM Lychnophora SPECIES

被引：12

作者：

Grael, Cristiane F. F. ^{[1
]}

Kanashiro, Alexandre ^{[1
]}

Kabeya, Luciana M. ^{[1
]}

Jordao, Christiane O. ^{[1
]}

takeara, Renata ^{[1
]}

Gobbo-Neto, Leonardo ^{[1
]}

Polizello, Ana Cristina M. ^{[1
]}

Lucisano-Valim, Yara M. ^{[1
]}

Lopes, Norberto P. ^{[1
]}

Lopes, Joao Luis C. ^{[1
]}

机构：

[1] Univ Sao Paulo, Dept Quim & Fis, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil

来源：

QUIMICA NOVA | 2010年 / 33卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

antioxidant activity; Lychnophora; flavonoids; TRYPANOCIDAL ACTIVITY; HUMAN NEUTROPHILS; OXIDATIVE STRESS; IMMUNE-COMPLEXES; FLAVONOIDS; CHEMILUMINESCENCE; INHIBITION; ASTERACEAE; CONSTITUENTS; STIMULATION;

D O I：

10.1590/S0100-40422010000400019

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This paper describes the antioxidant effects of thirteen phenolic compounds isolated from plants of the genus Lyehnophora. Two assays were performed to evaluate these effects: a cellular test that measured the luminol-enhanced chemiluminescence produced by neutrophils stimulated with opsonized zymosan and a cell-free test involving horseradish peroxidase-H2O2-luminol. In both assays. the antioxidant activity of the phenolic compounds was dependent on their concentration and chemical structure. Our results suggest that the ability of phenolic compounds from Lychnophora species to scavenge and inhibit the generation of ROS may be a mechanism underlying the anti-inflammatory activity of extracts from Lychnophora spp.

引用

页码：867 / 870

页数：4

共 30 条

[1] Phagocytes and oxidative stress [J].

Babior, BM .

AMERICAN JOURNAL OF MEDICINE, 2000, 109 (01) :33-44

[2]

Bazon J. N., 1997, Fitoterapia, V68, P92

[3] Transformation of flavonoids by intestinal microorganisms [J].

Blaut, M ;

Schoefer, L ;

Braune, A .

INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH, 2003, 73 (02) :79-87

[4] Analgesic activity of the lignans from Lychnophora ericoides [J].

Borsato, MLC ;

Grael, CFF ;

Souza, GEP ;

Lopes, NP .

PHYTOCHEMISTRY, 2000, 55 (07) :809-813

[5]

CHEUNG K, 1983, J IMMUNOL, V130, P2324

[6] Respiratory burst in human neutrophils [J].

Dahlgren, C ;

Karlsson, A .

JOURNAL OF IMMUNOLOGICAL METHODS, 1999, 232 (1-2) :3-14

[7] Antioxidant actions of polyphenols in humans [J].

Dragsted, LO .

INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH, 2003, 73 (02) :112-119

[8] Evaluation of the anti-inflammatory and antioxidant activities of di-C-glucosylflavones from Lychnophora ericoides (Asteraceae) [J].

Gobbo-Neto, L ;

Santos, MD ;

Kanashiro, A ;

Almeida, MC ;

Lucisano-Valim, YM ;

Lopes, JLC ;

Souza, GEP ;

Lopes, NP .

PLANTA MEDICA, 2005, 71 (01) :3-6

[9] Medicinal plants: Factors of influence on the content of secondary metabolites [J].

Gobbo-Neto, Leonardo ;

Lopes, Norberto P. .

QUIMICA NOVA, 2007, 30 (02) :374-381

[10]

Grael CFF, 2000, PHYTOTHER RES, V14, P203, DOI 10.1002/(SICI)1099-1573(200005)14:3<203::AID-PTR565>3.0.CO

← 1 2 3 →