Atorvastatin can ameliorate left atrial stunning induced by radiofrequency ablation for atrial fibrillation

被引：1

作者：

Xie, Ruiqin ^{[1
]}

Yang, Yingtao ^{[1
]}

Cui, Wei ^{[1
]}

Yin, Hongning ^{[1
]}

Zheng, Hongmei ^{[1
]}

Zhang, Jidong

You, Ling ^{[1
]}

机构：

[1] Hebei Med Univ, Dept Cardiol, Hosp 2, 215,West Heping Rd, Shijiazhuang 050000, Hebei, Peoples R China

来源：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2017年 / 95卷 / 09期

关键词：

atrial stunning; atorvastatin; radiofrequency ablation; atrial fibrillation; cardiac ultrasound; ultrasound speckle tracking imaging; CATHETER ABLATION; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; ELECTRICAL CARDIOVERSION; INFLAMMATION; MECHANISM; STATINS; FLUTTER;

D O I：

10.1139/cjpp-2016-0126

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The objective of this study was to study the functional changes of the left atrium after radiofrequency ablation treatment for atrial fibrillation and the therapeutic effect of atorvastatin. Fifty-eight patients undergoing radiofrequency ablation for atrial fibrillation were randomly divided into non-atorvastatin group and atorvastatin group. Patients in the atorvastatin group were treated with atorvastatin 20 mg p.o. per night in addition to the conventional treatment of atrial fibrillation; patients in the non-atorvastatin group received conventional treatment of atrial fibrillation only. Echocardiography was performed before radiofrequency ablation operation and 1 week, 2 weeks, 3 weeks, and 4 weeks after operation. Two-dimensional ultrasound speckle tracking imaging system was used to measure the structural indexes of the left atrium. Results indicated that there was no significant change for indexes representing the structural status of the left atrium within a month after radiofrequency ablation (P > 0.05); however, there were significant changes for indexes representing the functional status of the left atrium. There were also significant changes in indexes reflecting left atrial strain status: the S and SRs of atorvastatin group were higher than those of non-atorvastatin group (P < 0.05). In summary, atorvastatin could improve left atrial function and shorten the duration of atrial stunning after radiofrequency ablation of atrial fibrillation.

引用

页码：985 / 992

页数：8