HMNPPID-human malignant neoplasm protein-protein interaction database

被引：2

作者：

Li, Qingqing ^{[1
]}

Yang, Zhihao ^{[1
]}

Zhao, Zhehuan ^{[1
]}

Luo, Ling ^{[1
]}

Li, Zhiheng ^{[1
]}

Wang, Lei ^{[2
]}

Zhang, Yin ^{[2
]}

Lin, Hongfei ^{[1
]}

Wang, Jian ^{[1
]}

Zhang, Yijia ^{[1
]}

机构：

[1] Dalian Univ Technol, Coll Comp Sci & Technol, Dalian 116024, Peoples R China

[2] Beijing Inst Hlth Adm & Med Informat, Beijing 100850, Peoples R China

来源：

HUMAN GENOMICS | 2019年 / 13卷 / Suppl 1期

关键词：

Protein-protein interactions; Human malignant neoplasms; Database; INTERACTION NETWORK; EXPRESSION; RESOURCE; TUMORS; GENES; P53;

D O I：

10.1186/s40246-019-0223-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background Protein-protein interaction (PPI) information extraction from biomedical literature helps unveil the molecular mechanisms of biological processes. Especially, the PPIs associated with human malignant neoplasms can unveil the biology behind these neoplasms. However, such PPI database is not currently available. Results In this work, a database of protein-protein interactions associated with 171 kinds of human malignant neoplasms named HMNPPID is constructed. In addition, a visualization program, named VisualPPI, is provided to facilitate the analysis of the PPI network for a specific neoplasm. Conclusions HMNPPID can hopefully become an important resource for the research on PPIs of human malignant neoplasms since it provides readily available data for healthcare professionals. Thus, they do not need to dig into a large amount of biomedical literatures any more, which may accelerate the researches on the PPIs of malignant neoplasms.

引用

页数：10

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