Intrathecal CART (55-102) enhances the spinal analgesic actions of morphine in mice

被引：29
作者：
Damaj, MI
Hunter, RG
Martin, BR
Kuhar, MJ
机构：
[1] Virginia Commonwealth Univ, Med Coll, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA
[2] Emory Univ, Yerkes Reg Primate Res Ctr, Atlanta, GA 30329 USA
来源：
BRAIN RESEARCH | 2004年 / 1024卷 / 1-2期
关键词：
cocaine; brain; spinal cord;
D O I：
10.1016/j.brainres.2004.07.058
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cocaine- and amphetamine-regulated transcript (CART) peptides are found in brain and spinal cord areas involved in pain transmission. In the present study, we investigated the role of rat CART (55-102) in the modulation of an acute pain model after intrathecal administration. The results show that CART (55-102) was without effect on the tail-flick test after i.t. injection in mice. Interestingly, i.t. administration of CART (55-102) significantly enhanced the antinociceptive effect of morphine in the tail-flick test. These results suggest that CART (55-102) potentiates the effects of opioids to inhibit the nociceptive information transmission. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：146 / 149
页数：4
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