Palladium-catalyzed borylation of aryl chlorides: Scope, applications, and computational studies

被引：308

作者：

Billingsley, Kelvin L. ^{[1
]}

Barder, Timothy E. ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 28期

关键词：

boronate esters; borylation; C-C coupling; palladium; Suzuki-Miyaura coupling;

D O I：

10.1002/anie.200701551

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) From chloride to boronate: Catalysts comprising palladium and biaryl monophosphine ligands provide highly active systems for the borylation of aryl and heteroaryl chlorides (see scheme). Symmetrical and unsymmetrical biaryl products can also be prepared directly from two aryl chlorides without isolation of the intermediate boronate esters. Computational studies provide insight into the roles of the biaryl phosphine ligand and the KOAc base in the catalytic cycle. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5359 / 5363

页数：5

共 27 条

[1]

[Anonymous], 2002, J ORGANOMET CHEM

[2] Catalysts for Suzuki-Miyaura coupling processes: Scope and studies of the effect of ligand structure [J].