Sleep Disturbance and Ovarian Stimulation Outcomes in Infertility and Fertility Preservation Patients

OBJECTIVE: To assess sleep patterns and ovarian stimulation outcomes in infertile as compared to fertility preservation (FP) patients with a concurrent cancer diagnosis undergoing controlled ovarian hyperstimulation (COH). STUDY DESIGN: Prospective survey study done at a single academic medical center examining sleep disturbance, medical diagnoses, anti-Mullerian hormone (AMH), and COH stimulation results using CES-D scale in 50 infertile and 32 age-matched FP patients. RESULTS: Sleep disturbance was significantly higher at baseline in FP patients. Over time, sleep disturbance significantly increased in infertile patients (T1 MOS-SS SCORE= 16; T2 MOS-SS SCORE= 20) but not in FP patients (T1 MOS-SS SCORE= 32; T2 MOS-SS SCORE= 36). Sleep disturbance did correlate with CES-D scores for both infertile and FP patients. How-ever, no correlations were found between sleep disturbance and AMH, peak estradiol, total medication received, number of oocytes retrieved, and number of oocytes frozen. CONCLUSION: Sleep scores for infertile patients significantly increased, often reaching values equivalent to national levels cited for chronic illnesses. For both infertile and FP patients, sleep scores correlated with CES-D scores but did not correlate with ovarian stimulation outcomes.