Perspective: Pivotal translational hematology and therapeutic insights in chronic myeloid hematopoietic stem cell malignancies

被引：0

作者：

Mughal, Tariq, I ^{[1
,2
]}

Pemmaraju, Naveen ^{[3
]}

Bejar, Rafael ^{[4
]}

Gale, Robert P. ^{[5
]}

Bose, Prithviraj ^{[3
]}

Kiladjian, Jean-Jacques ^{[6
]}

Prchal, Josef ^{[7
]}

Royston, Daniel ^{[8
]}

Pollyea, Daniel ^{[9
]}

Valent, Peter ^{[10
,11
]}

Brummendorf, Tim H. ^{[12
]}

Skorski, Tomasz ^{[13
]}

Patnaik, Mrinal ^{[14
]}

Santini, Valeria ^{[15
]}

Fenaux, Pierre ^{[16
]}

Kucine, Nicole ^{[17
]}

Verstovsek, Srdan ^{[3
]}

Mesa, Ruben ^{[18
]}

Barbui, Tiziano ^{[19
]}

Saglio, Guiseppe ^{[20
]}

Van Etten, Richard A. ^{[21
]}

机构：

[1] Tufts Univ, Sch Med, Boston, MA 02111 USA

[2] Univ Buckingham, Buckingham, England

[3] Univ Texas Houston, MD Anderson Canc Ctr, 1515 Holcombe Blvd, Houston, TX 77030 USA

[4] Univ Calif San Diego, La Jolla, CA 92093 USA

[5] Imperial Coll, London, England

[6] Univ Paris, INSERM, Hop St Louis, Paris, France

[7] Huntsman Canc Ctr, Salt Lake City, UT USA

[8] Univ Oxford, John Radcliffe Hosp, Oxford, England

[9] Univ Colorado, Sch Med, Aurora, CO USA

[10] Med Univ Vienna, Vienna, Austria

[11] Med Univ Vienna, Ludwig Boltzmann Inst Hematol & Oncol, Vienna, Austria

[12] Univ Hosp RWTH, Aachen, Germany

[13] Temple Univ, Lewis Katz Sch Med, Philadelphia, PA 19122 USA

[14] Mayo Clin, Rochester, MN USA

[15] Univ Florence, Azienda Osped Univ Careggi, Florence, Italy

[16] Hosp St Louis, AP HP, Paris, France

[17] Weill Cornell Med, New York, NY USA

[18] UT Hlth San Antonio MD Anderson Canc Ctr, Mays Canc Ctr, San Antonio, TX USA

[19] Fdn Ric Osped Maggiore Bergamo, Bergamo, Italy

[20] Univ Turin, Turin, Italy

[21] Univ Calif Irvine, Chao Family Comprehens Canc Ctr, Irvine, CA USA

来源：

HEMATOLOGICAL ONCOLOGY | 2022年 / 40卷 / 04期

关键词：

chronic myeloid leukemia; clinical; Myelofibrosis; systemic mastocytosis; thrombosis; translational; CHRONIC MYELOGENOUS LEUKEMIA; SYNTHETIC LETHALITY; POLYCYTHEMIA-VERA; MYELOPROLIFERATIVE NEOPLASMS; SYSTEMIC MASTOCYTOSIS; GENOMIC INSTABILITY; RESPONSE CRITERIA; TP53; MUTATIONS; CLASSIFICATION; RUXOLITINIB;

D O I：

10.1002/hon.2987

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite much of the past 2 years being engulfed by the devastating consequences of the SAR-CoV-2 pandemic, significant progress, even breathtaking, occurred in the field of chronic myeloid malignancies. Some of this was show-cased at the 15th Post-American Society of Hematology (ASH) and the 25th John Goldman workshops on myeloproliferative neoplasms (MPN) held on 9th-10th December 2020 and 7th-10th October 2021, respectively. The inaugural Post-ASH MPN workshop was set out in 2006 by John Goldman (deceased) and Tariq Mughal to answer emerging translational hematology and therapeutics of patients with these malignancies. Rather than present a resume of the discussions, this perspective focuses on some of the pivotal translational hematology and therapeutic insights in these diseases.

引用

页码：491 / 504

页数：14

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