Hyperglycemia as a possible risk factor for mold infections-the potential preventative role of intensified glucose control in allogeneic hematopoietic stem cell transplantation

被引：22

作者：

Fuji, S. ^{[1
,2
]}

Loeffler, J. ^{[2
]}

Savani, B. N. ^{[3
,4
]}

Einsele, H. ^{[2
]}

Kapp, M. ^{[2
]}

机构：

[1] Natl Canc Ctr, Dept Hematopoiet Stem Cell Transplantat, Tokyo, Japan

[2] Univ Hosp Wurzburg, Div Hematol Oncol, Dept Internal Med 2, Wurzburg, Germany

[3] Vanderbilt Univ, Med Ctr, Dept Med, Hematol & Stem Cell Transplantat Sect,Div Hematol, Nashville, TN USA

[4] Vet Affairs Med Ctr, Nashville, TN 37212 USA

来源：

BONE MARROW TRANSPLANTATION | 2017年 / 52卷 / 05期

关键词：

INVASIVE FUNGAL-INFECTIONS; BRONCHOALVEOLAR MACROPHAGE DEFENSE; ACUTE MYELOID-LEUKEMIA; VERSUS-HOST-DISEASE; DIABETES-MELLITUS; ASPERGILLUS; RECIPIENTS; EPIDEMIOLOGY; MUCORMYCOSIS; ZYGOMYCOSIS;

D O I：

10.1038/bmt.2016.306

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Diabetes mellitus (DM) is well-known as a disorder that increases the risk of infectious diseases. Various reports have shown that innate immunity is impaired in patients with DM, which is considered to be a major cause of increased risk of infectious diseases. However, there is a paucity of data about the actual risk of mold infections in patients with DM. Several treatment procedures, such as solid organ transplantation and hematopoietic stem cell transplantation (HSCT), are intrinsically associated with a high risk of mold infections and also correlated with an increased risk of post-transplant DM. Therefore, we could assume that organ transplant recipients or HSCT recipients with DM are at quite high risk of mold infections. Here, we aim to summarize the information about the increased risk of mold infections in patients with DM, and propose possible interventions such as intensive glucose control to reduce this risk in patients with DM.

引用

页码：657 / 662

页数：6

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