Diabetes drugs in the fight against Alzheimer's disease

被引：112
作者：
Boccardi, Virginia [1 ]
Murasecco, Ilenia [1 ]
Mecocci, Patrizia [1 ]
机构：
[1] Univ Perugia, St Maria Misericordia Hosp, Dept Med, Inst Gerontol & Geriatr, Piazzale Gambuli 1, I-06132 Perugia, Italy
来源：
AGEING RESEARCH REVIEWS | 2019年 / 54卷
关键词：
Alzheimer's; Diabetes; Insulin; Drugs; Cognition; ACUTE GLUCOSE FLUCTUATIONS; GLUCAGON-LIKE PEPTIDE-1; GROWTH-FACTOR-I; OXIDATIVE STRESS; TAU PHOSPHORYLATION; INTRANASAL INSULIN; MEMORY IMPAIRMENT; A-BETA; DIPEPTIDYL PEPTIDASE-4; ANTIDIABETIC DRUGS;
D O I：
10.1016/j.arr.2019.100936
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Alzheimer's disease (AD) is the most prevalent form of dementia, particularly in old age subjects. Hyperinsulinemia and insulin resistance, which are known as pathophysiological features of Type 2 Diabetes Mellitus (T2DM), have also been demonstrated to have a significant impact on cognitive impairment. Studies have shown that an altered insulin pathway may interact with amyloid-beta protein deposition and tau protein phosphorylation, both leading factors for AD development. Drugs used for T2DM treatment from insulin and metformin through dipeptidyl peptidase-4 inhibitors and glucagon-like peptide-1 receptor agonists may represent a promising approach to fight AD. With this review from animal to human studies, we aim at responding to the reasons why drugs for diabetes may represent potential treatments for AD.
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页数：8
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共 96 条
[1]   Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology [J].
Abner, Erin L. ;
Nelson, Peter T. ;
Kryscio, Richard J. ;
Schmitt, Frederick A. ;
Fardo, David W. ;
Woltjer, Randall L. ;
Cairns, Nigel J. ;
Yu, Lei ;
Dodge, Hiroko H. ;
Xiong, Chengjie ;
Masaki, Kamal ;
Tyas, Suzanne L. ;
Bennett, David A. ;
Schneider, Julie A. ;
Arvanitakis, Zoe .
ALZHEIMERS & DEMENTIA, 2016, 12 (08) :882-889
[2]   Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex [J].
Ansari, Mubeen A. ;
Scheff, Stephen W. .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2010, 69 (02) :155-167
[3]   Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums [J].
Arnold, Steven E. ;
Arvanitakis, Zoe ;
Macauley-Rambach, Shannon L. ;
Koenig, Aaron M. ;
Wang, Hoau-Yan ;
Ahima, Rexford S. ;
Craft, Suzanne ;
Gandy, Sam ;
Buettner, Christoph ;
Stoeckel, Luke E. ;
Holtzman, David M. ;
Nathan, David M. .
NATURE REVIEWS NEUROLOGY, 2018, 14 (03) :168-181
[4]   The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action [J].
Athauda, Dilan ;
Foltynie, Thomas .
DRUG DISCOVERY TODAY, 2016, 21 (05) :802-818
[5]   Decreased carotid atherosclerotic process by control of daily acute glucose fluctuations in diabetic patients treated by DPP-IV inhibitors [J].
Barbieri, M. ;
Rizzo, M. R. ;
Marfella, R. ;
Boccardi, V. ;
Esposito, A. ;
Pansini, A. ;
Paolisso, G. .
ATHEROSCLEROSIS, 2013, 227 (02) :349-354
[6]   Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes [J].
Bhutada, Pravinkumar ;
Mundhada, Yogita ;
Bansod, Kuldeep ;
Tawari, Santosh ;
Patil, Shaktipal ;
Dixit, Pankaj ;
Umathe, Sudhir ;
Mundhada, Dharmendra .
BEHAVIOURAL BRAIN RESEARCH, 2011, 220 (01) :30-41
[7]   Insulin in the brain: its pathophysiological implications for states related with central insulin resistance, type 2 diabetes and alzheimer's disease [J].
Blazquez, Enrique ;
Velazquez, Esther ;
Hurtado-Carneiro, Veronica ;
Miguel Ruiz-Albusac, Juan .
FRONTIERS IN ENDOCRINOLOGY, 2014, 5
[8]   An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Aβ oligomers [J].
Bomfim, Theresa R. ;
Forny-Germano, Leticia ;
Sathler, Luciana B. ;
Brito-Moreira, Jordano ;
Houzel, Jean-Christophe ;
Decker, Helena ;
Silverman, Michael A. ;
Kazi, Hala ;
Melo, Helen M. ;
McClean, Paula L. ;
Holscher, Christian ;
Arnold, Steven E. ;
Talbot, Konrad ;
Klein, William L. ;
Munoz, Douglas P. ;
Ferreira, Sergio T. ;
De Felice, Fernanda G. .
JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (04) :1339-1353
[9]   Ten years of protein kinase B signalling: a hard Akt to follow [J].
Brazil, DP ;
Hemmings, BA .
TRENDS IN BIOCHEMICAL SCIENCES, 2001, 26 (11) :657-664
[10]   Plasminogen Activator Inhibitor-1 (PAI-1): A Key Factor Linking Fibrinolysis and Age-Related Subclinical and Clinical Conditions [J].
Cesari, Matteo ;
Pahor, Marco ;
Incalzi, Raffaele Antonelli .
CARDIOVASCULAR THERAPEUTICS, 2010, 28 (05) :e72-e91
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