Brain-derived neurotrophic factor as a drug target for CNS disorders

被引：126
作者：
Pezet, S
Malcangio, M
机构：
[1] Novartis Inst Med Sci, London WC1E 6BS, England
[2] Kings Coll London, Ctr Age Related Dis, London SE1 1UL, England
来源：
EXPERT OPINION ON THERAPEUTIC TARGETS | 2004年 / 8卷 / 05期
关键词：
brain-derived neurotrophic factor (BDNF); neuroprotection; synaptic activity;
D O I：
10.1517/14728222.8.5.391
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of trophic factors. BDNF is widely and abundantly expressed in the CNS and is available to some peripheral nervous system neurons that uptake the neurotrophin produced by peripheral tissues. BDNF promotes survival and differentiation of certain neuronal populations during development. In adulthood, BDNF can modulate neuronal synaptic strength and has been implicated in hippocampal mechanisms of learning and memory and spinal mechanisms for pain. Several CNS disorders are associated with a decrease in trophic support. As BDNF and its high affinity receptor are abundant throughout the whole CNS, and BDNF is a potent neuroprotective agent, this trophic factor is a good candidate for therapeutic treatment of some of CNS disorders. This review aims to correlate the features of some CNS disorders (Parkinson's disease, Alzheimer's disease, depression, epilepsy and chronic pain) to changes in BDNF expression in the brain. The cellular and molecular mechanism by which BDNF might be a therapeutic strategy are critically examined.
引用
收藏
页码：391 / 399
页数：9
相关论文
共 112 条
[21]   ACTIVATION OF MAP KINASE KINASE IS NECESSARY AND SUFFICIENT FOR PC12 DIFFERENTIATION AND FOR TRANSFORMATION OF NIH 3T3 CELLS [J].
COWLEY, S ;
PATERSON, H ;
KEMP, P ;
MARSHALL, CJ .
CELL, 1994, 77 (06) :841-852
[22]   Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex [J].
Croll, SD ;
Suri, C ;
Compton, DL ;
Simmons, MV ;
Yancopoulos, GD ;
Lindsay, RM ;
Wiegand, SJ ;
Rudge, YS ;
Scharfman, HE .
NEUROSCIENCE, 1999, 93 (04) :1491-1506
[23]   REGULATION OF NEUROPEPTIDES IN ADULT-RAT FOREBRAIN BY THE NEUROTROPHINS BDNF AND NGF [J].
CROLL, SD ;
WIEGAND, SJ ;
ANDERSON, KD ;
LINDSAY, RM ;
NAWA, H .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1994, 6 (08) :1343-1353
[24]   Differential regulation of brain derived neurotrophic factor transcripts by antidepressant treatments in the adult rat brain [J].
Dias, BG ;
Banerjee, SB ;
Duman, RS ;
Vaidya, VA .
NEUROPHARMACOLOGY, 2003, 45 (04) :553-563
[25]   Synaptic plasticity and mood disorders [J].
Duman, RS .
MOLECULAR PSYCHIATRY, 2002, 7 (Suppl 1) :S29-S34
[26]   Role of neurotrophic factors in the etiology and treatment of mood disorders [J].
Duman, RS .
NEUROMOLECULAR MEDICINE, 2004, 5 (01) :11-25
[27]   Amelioration of chronic neuropathic pain after partial nerve injury by adeno-associated viral (AAV) vector-mediated over-expression of BDNF in the rat spinal cord [J].
Eaton, MJ ;
Blits, B ;
Ruitenberg, MJ ;
Verhaagen, J ;
Oudega, M .
GENE THERAPY, 2002, 9 (20) :1387-1395
[28]   EXPRESSION OF MESSENGER-RNAS FOR NEUROTROPHIN RECEPTORS IN THE DORSAL-ROOT GANGLION AND SPINAL-CORD DURING DEVELOPMENT AND FOLLOWING PERIPHERAL OR CENTRAL AXOTOMY [J].
ERNFORS, P ;
ROSARIO, CM ;
MERLIO, JP ;
GRANT, G ;
ALDSKOGIUS, H ;
PERSSON, H .
MOLECULAR BRAIN RESEARCH, 1993, 17 (3-4) :217-226
[29]   MOLECULAR-CLONING AND NEUROTROPHIC ACTIVITIES OF A PROTEIN WITH STRUCTURAL SIMILARITIES TO NERVE GROWTH-FACTOR - DEVELOPMENTAL AND TOPOGRAPHICAL EXPRESSION IN THE BRAIN [J].
ERNFORS, P ;
IBANEZ, CF ;
EBENDAL, T ;
OLSON, L ;
PERSSON, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) :5454-5458
[30]   BDNF and full-length and truncated TrkB expression in Alzheimer disease.: Implications in therapeutic strategies [J].
Ferrer, I ;
Marín, C ;
Rey, MJ ;
Ribalta, T ;
Goutan, E ;
Blanco, R ;
Tolosa, E ;
Martí, E .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1999, 58 (07) :729-739
12345678910