Selection of different endothelialization modes and different seed cells for tissue-engineered vascular graft

被引:42
作者
Cai, Qingjin [1 ]
Liao, Wanshan [1 ]
Xue, Fangchao [1 ]
Wang, Xiaochen [1 ]
Zhou, Weiming [1 ]
Li, Yanzhao [2 ]
Zeng, Wen [1 ,2 ,3 ]
机构
[1] Third Mil Med Univ, Dept Cell Biol, Chongqing 400038, Peoples R China
[2] State Key Lab Trauma Burn & Combined Injury, Chongqing, Peoples R China
[3] Third Mil Med Univ, Southwest Hosp, Dept Neurol, Chongqing, Peoples R China
基金
美国国家科学基金会;
关键词
Tissue-engineered vascular grafts; scaffold materials; seed cells; vascular endothelialization; endothelial heterogeneity; PLURIPOTENT STEM-CELLS; SMOOTH-MUSCLE-CELLS; PROGENITOR CELLS; BLOOD-VESSELS; FUNCTIONAL-CHARACTERIZATION; CORD BLOOD; SCAFFOLDS; COLLAGEN; HETEROGENEITY; BYPASS;
D O I
10.1016/j.bioactmat.2020.12.021
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Tissue-engineered vascular grafts (TEVGs) have enormous potential for vascular replacement therapy. However, thrombosis and intimal hyperplasia are important problems associated with TEVGs especially small diameter TEVGs (<6 mm) after transplantation. Endothelialization of TEVGs is a key point to prevent thrombosis. Here, we discuss different types of endothelialization and different seed cells of tissue-engineered vascular grafts. Meanwhile, endothelial heterogeneity is also discussed. Based on it, we provide a new perspective for selecting suitable types of endothelialization and suitable seed cells to improve the long-term patency rate of tissue-engineered vascular grafts with different diameters and lengths.
引用
收藏
页码:2557 / 2568
页数:12
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