Utility of pyrosequencing for rapid detection of tubercular meningitis (TBM) and associated susceptibility directly from CSF specimens

被引：9

作者：

Ajbani, Kanchan ^{[1
]}

Kazi, Mubin ^{[1
]}

Naik, Swapna ^{[1
]}

Soman, Rajeev ^{[2
]}

Shetty, Anjali ^{[1
]}

Rodrigues, Camilla ^{[1
]}

机构：

[1] PD Hinduja Hosp & Med Res Ctr, Dept Microbiol, Veer Sarvarkar Marg, Bombay 400016, Maharashtra, India

[2] PD Hinduja Hosp & Med Res Ctr, Dept Med, Veer Sarvarkar Marg, Bombay, Maharashtra, India

来源：

TUBERCULOSIS | 2018年 / 111卷

关键词：

RESISTANT MYCOBACTERIUM-TUBERCULOSIS; XPERT MTB/RIF ASSAY; DIAGNOSIS; PERFORMANCE;

D O I：

10.1016/j.tube.2018.05.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tubercular meningitis (TBM) is a serious form of tuberculosis (TB). The diagnosis of TBM & susceptibility/resistance is difficult as TB MGIT culture lacks sensitivity & timeliness. Timely and accurate diagnosis of the TBM is the need of the hour for initiation of appropriate therapy. We have exploited pyrosequencing to detect TB and associated Multi/extensively drug resistant (MDR/ XDR-TB) directly from Cerebrospinal Fluid (CSF) specimens.

引用

页码：54 / 56

页数：3

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