Inhibition of ovalbumin-induced allergic rhinitis by sumatriptan through the nitric oxide pathway in mice

被引:13
作者
Hemmati, Sara [1 ]
Rahimi, Nastaran [1 ,2 ]
Dabiri, Sasan [3 ]
Alaeddini, Mojgan [4 ]
Etemad-Moghadam, Shahroo [4 ]
Dehpour, Ahmad Reza [1 ,2 ]
机构
[1] Univ Tehran Med Sci, Expt Med Res Ctr, Tehran, Iran
[2] Univ Tehran Med Sci, Dept Pharmacol, Fac Med, Tehran, Iran
[3] Univ Tehran Med Sci, Dept Otorhinolaryngol Head & Neck Surg, Otorhinolaryngol Res Ctr, Tehran, Iran
[4] Univ Tehran Med Sci, Dent Res Inst, Dent Res Ctr, Tehran, Iran
基金
美国国家科学基金会;
关键词
Sumatriptan; Allergic rhinitis; Mice; Nitric oxide; 5HT1B/1D receptors; MAST-CELLS; ASTHMA; SEROTONIN; MIGRAINE; MECHANISMS; RECEPTORS; INFLAMMATION; EXPRESSION; HISTAMINE; SYMPTOMS;
D O I
10.1016/j.lfs.2019.116901
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Aims: Allergic rhinitis is a global cause of disability, characterized by airway inflammation. Sumatriptan is a 5-hydroxytryptamine 1B/1D (5HT1B/1D) agonist used as a treatment for migraine headaches. Activation of 5HT1B/1D receptors can inhibit the release of neuropeptides and inhibit the inflammation cascades. This study investigated the effect of sumatriptan on ovalbumin-induced allergic rhinitis model in mice and the role of nitric oxide. Methods: Female Balb/c mice were sensitized by intraperitoneal ovalbumin and challenged by intranasal ovalbumin. Mice received sumatriptan in doses 3, 10, 30 mu g/kg intraperitoneally, 30 min before the last ovalbumin challenge. Key findings: Intraperitoneal injection of sumatriptan significantly decreased the nasal scratching, IL-4 and serum IgE levels of allergic mice, but it increased IFN gamma levels. Histopathological analysis showed that the number of eosinophils was significantly elevated in nasal mucosa of ovalbumin-induced allergic mice, while sumatriptan treatment significantly reduced the number of eosinophils. GR-127935, a selective 5-HT1B/1D-receptor antagonist, reversed the anti-allergic effects of sumatriptan. Acute administration of L-NAME, a non-specific inhibitor of nitric oxide synthase, along with sumatriptan attenuated the anti-allergic effects of sumatriptan but chronic administration of L-NAME did not affect the influences of sumatriptan. Furthermore, sumatriptan decreased the inducible nitric oxide synthase (iNOS) protein expression in allergic mice, but it did not change the concentration of eNOS protein. Significance: This study shows that sumatriptan administration is associated with anti-allergic effects which are through 5HT1B/1D receptors. Decrease in iNOS expression and changes in T-helper 1&2 cytokines levels may indicate the involvement of inducible NOS and inflammation.
引用
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页数:10
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