Assignment of the orphan nuclear receptor Nurr1 by NMR

被引：10

作者：

Michiels, Paul ^{[1
]}

Atkins, Karen ^{[2
]}

Ludwig, Christian ^{[2
]}

Whittaker, Sara ^{[2
]}

van Dongen, Maria ^{[1
]}

Guenther, Ulrich ^{[2
]}

机构：

[1] Solvay Pharmaceut Res Labs, Hannover, Germany

[2] Univ Birmingham, Inst Canc Sci, Birmingham B15 2TT, W Midlands, England

来源：

BIOMOLECULAR NMR ASSIGNMENTS | 2010年 / 4卷 / 01期

基金：

英国惠康基金;

关键词：

Orphan nuclear receptor; NMR; Nurr1; Parkinson's disease; NR4A nuclear receptors; LIGAND-BINDING DOMAIN; PARKINSONS-DISEASE; RXR-ALPHA; EXPRESSION; RESONANCE;

D O I：

10.1007/s12104-010-9210-4

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The orphan nuclear receptor Nurr1 has been implicated in a number of conditions including Parkinson's disease and Schizophrenia. As such, it is of interest to study its interactions with other proteins, possibly mediated by small molecules, considering possible use as a drug target. We produced H-2, N-15, C-13 labelled-Nurr1 to generate the backbone amide NH, carbonyl C', C-alpha and C-beta assignments. About 84.0% of residues could be assigned. Most of the 37 missing assignments fall in 3 regions of the protein. Two of these surround a putative ligand-binding region of Nurr1, suggesting that this region of the protein is flexible, despite the ligand-binding pocket being filled with hydrophobic side-chains from residues surrounding the ligand binding pocket.

引用

页码：101 / 105

页数：5

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