Human Brown Adipose Tissue

被引:304
作者
Enerback, Sven [1 ]
机构
[1] Univ Gothenburg, Inst Biomed, Dept Med & Clin Genet, SE-40530 Gothenburg, Sweden
基金
瑞典研究理事会;
关键词
DIET-INDUCED THERMOGENESIS; ADULT HUMANS; OBESITY; UCP1; FAT;
D O I
10.1016/j.cmet.2010.03.008
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The BAT organ is unique in that it has evolved to safely dissipate large amounts of chemical energy a quality that might be harnessed to help humans deal with a dangerously hypercaloric environment and still remain in good health.
引用
收藏
页码:248 / 252
页数:5
相关论文
共 27 条
[11]  
HIMMSHAGEN J, 1979, CAN MED ASSOC J, V121, P1361
[12]   THE OCCURRENCE OF BROWN ADIPOSE-TISSUE IN OUTDOOR WORKERS [J].
HUTTUNEN, P ;
HIRVONEN, J ;
KINNULA, V .
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY, 1981, 46 (04) :339-345
[13]   Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis [J].
Jastroch, M. ;
Withers, K. W. ;
Taudien, S. ;
Frappell, P. B. ;
Helwig, M. ;
Fromme, T. ;
Hirschberg, V. ;
Heldmaier, G. ;
McAllan, B. M. ;
Firth, B. T. ;
Burmester, T. ;
Platzer, M. ;
Klingenspor, M. .
PHYSIOLOGICAL GENOMICS, 2008, 32 (02) :161-169
[14]   Functional characterisation of UCP1 in the common carp: uncoupling activity in liver mitochondria and cold-induced expression in the brain [J].
Jastroch, Martin ;
Buckingham, Julie A. ;
Helwig, Michael ;
Klingenspor, Martin ;
Brand, Martin D. .
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY, 2007, 177 (07) :743-752
[15]  
LEAN MEJ, 1986, INT J OBESITY, V10, P219
[16]  
Lichtenbelt WDV, 2009, NEW ENGL J MED, V360, P1500, DOI 10.1056/NEJMoa0808718
[17]   UPTAKE OF GLUCOSE AND RELEASE OF FATTY-ACIDS AND GLYCEROL BY RAT BROWN ADIPOSE-TISSUE INVIVO [J].
MA, SWY ;
FOSTER, DO .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1986, 64 (05) :609-614
[18]   Quantitative MRI-based temperature mapping based on the proton resonant frequency shift: Review of validation studies [J].
McDannold, N .
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 2005, 21 (06) :533-546
[19]   Thermoregulation: What role for UCPs in mammals and birds? [J].
Mozo, J ;
Emre, Y ;
Bouillaud, F ;
Ricquier, D ;
Criscuolo, F .
BIOSCIENCE REPORTS, 2005, 25 (3-4) :227-249
[20]   Expression of Uncoupling Protein 1 in Mouse Brown Adipose Tissue Is Thyroid Hormone Receptor-β Isoform Specific and Required for Adaptive Thermogenesis [J].
Ribeiro, Miriam O. ;
Bianco, Suzy D. C. ;
Kaneshige, Masahiro ;
Schultz, James J. ;
Cheng, Sheue-yann ;
Bianco, Antonio C. ;
Brent, Gregory A. .
ENDOCRINOLOGY, 2010, 151 (01) :432-440