Age-Related Inflammation: the Contribution of Different Organs, Tissues and Systems. How to Face it for Therapeutic Approaches

被引：142
作者：
Cevenini, E. [3 ,4 ]
Caruso, C. [1 ]
Candore, G. [1 ]
Capri, M. [3 ,4 ]
Nuzzo, D. [2 ]
Duro, G. [2 ]
Rizzo, C. [1 ]
Colonna-Romano, G. [1 ]
Lio, D. [1 ]
Di Carlo, D. [1 ]
Palmas, M. G. [3 ,4 ]
Scurti, M. [3 ,4 ]
Pini, E. [3 ,4 ]
Franceschi, C. [3 ,4 ]
Vasto, S. [1 ]
机构：
[1] Univ Palermo, Dept Pathobiol & Biomed Methodol, Immunosenescence Unit, I-90134 Palermo, Italy
[2] CNR, IBIM, Palermo, Italy
[3] Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy
[4] Univ Bologna, CIG Interdepartmental Ctr L Galvani Integrated St, I-40126 Bologna, Italy
来源：
CURRENT PHARMACEUTICAL DESIGN | 2010年 / 16卷 / 06期
关键词：
Ageing; age-related diseases; immunosenescence; inflammation; GROWTH-FACTOR-I; CD8(+) T-CELLS; CYTOMEGALOVIRUS-INFECTION; ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; MUSCLE STRENGTH; IMMUNE-SYSTEM; EVOLUTIONARY PERSPECTIVE; INFLUENZA VACCINATION; MEDITERRANEAN DIET;
D O I：
10.2174/138161210790883840
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A typical feature of ageing is a chronic, low-grade inflammation characterized by a general increase in the production of pro-inflammatory cytokines and inflammatory markers ("inflamm-ageing"). This status may slowly damage one or several organs, especially when unfavorable genetic polymorphisms and epigenetic alterations are concomitant, leading to an increased risk of frailty together with the onset of age-related chronic diseases. The contribution of different tissues (adipose tissue, muscle), organs (brain, liver), immune system and ecosystems (gut microbiota) to age-related inflammation ("inflamm-ageing") will be discussed in this review in the context of its onset/progression leading to site-restricted and systemic effects. Moreover, some of the possible strategies and therapies to counteract the different sources of molecular mediators which lead to the age-related inflammatory phenotype will be presented.
引用
收藏
页码：609 / 618
页数：10
相关论文
共 142 条
[1]   Aging liver [J].
Anantharaju, A ;
Feller, A ;
Chedid, A .
GERONTOLOGY, 2002, 48 (06) :343-353
[2]   Gene transfer for activation of CMV specific T cells [J].
André-Schmutz, I ;
Dal Cortivo, L ;
Hamel, Y ;
Cavazzana-Calvo, M .
HUMAN IMMUNOLOGY, 2004, 65 (05) :565-570
[3]  
Arii S, 2000, J Hepatobiliary Pancreat Surg, V7, P40, DOI 10.1007/s005340050152
[4]   Effect of influenza vaccination on excess deaths occurring during periods of high circulation of influenza: cohort study in elderly people [J].
Armstrong, BG ;
Mangtani, P ;
Fletcher, A ;
Kovats, S ;
McMichael, A ;
Pattenden, S ;
Wilkinson, P .
BMJ-BRITISH MEDICAL JOURNAL, 2004, 329 (7467) :660-663
[5]   Host-bacterial mutualism in the human intestine [J].
Bäckhed, F ;
Ley, RE ;
Sonnenburg, JL ;
Peterson, DA ;
Gordon, JI .
SCIENCE, 2005, 307 (5717) :1915-1920
[6]   Association between the Polymorphisms of TLR4 and CD14 Genes and Alzheimer's Disease [J].
Balistreri, C. R. ;
Grimaldi, M. P. ;
Chiappelli, M. ;
Licastro, F. ;
Castiglia, L. ;
Listi, F. ;
Vasto, S. ;
Lio, D. ;
Caruso, C. ;
Candore, G. .
CURRENT PHARMACEUTICAL DESIGN, 2008, 14 (26) :2672-2677
[7]   Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons [J].
Barbieri, M ;
Ferrucci, L ;
Ragno, E ;
Corsi, A ;
Bandinelli, S ;
Bonafè, M ;
Olivieri, F ;
Giovagnetti, S ;
Franceschi, C ;
Guralnik, JM ;
Paolisso, G .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2003, 284 (03) :E481-E487
[8]  
Barbosa KBF, 2008, AN SIST SANIT NAVAR, V31, P259, DOI 10.4321/s1137-66272008000500006
[9]   Predictors of skeletal muscle mass in elderly men and women [J].
Baumgartner, RN ;
Waters, DL ;
Gallagher, D ;
Morley, JE ;
Garry, PJ .
MECHANISMS OF AGEING AND DEVELOPMENT, 1999, 107 (02) :123-136
[10]   Thymic regeneration: teaching an old immune system new tricks [J].
Berzins, SP ;
Uldrich, AP ;
Sutherland, JS ;
Gill, J ;
Miller, JFAP ;
Godfrey, DI ;
Boyd, RL .
TRENDS IN MOLECULAR MEDICINE, 2002, 8 (10) :469-476
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