Anti-inflammatory activity of essential oil from leaves of Myrciaria tenella and Calycorectes sellowianus

被引：35
|
作者：
Apel, Miriam A. [1 ]
Lima, Marcos E. L. [1 ]
Sobral, Marcos [2 ]
Young, Maria Claudia M. [3 ]
Cordeiro, Ines [3 ]
Schapoval, Elfrides E. S. [4 ]
Henriques, Amelia T. [4 ]
Moreno, Paulo Roberto H. [1 ]
机构：
[1] Univ Sao Paulo, Inst Quim, BR-05508000 Sao Paulo, Brazil
[2] Univ Fed Minas Gerais, Dept Bot, Belo Horizonte, MG, Brazil
[3] Secretaria Meio Ambiente Sao Paulo, Inst Bot, Sao Paulo, Brazil
[4] Univ Fed Rio Grande do Sul, Fac Farm, Curso Posgrad Ciencias Farmaceut, Porto Alegre, RS, Brazil
来源：
PHARMACEUTICAL BIOLOGY | 2010年 / 48卷 / 04期
基金：
巴西圣保罗研究基金会;
关键词：
Myrciaria tenella; Calycorectes sellowianus; Myrtaceae; essential oil; anti-inflammatory activity; CHEMICAL-COMPOSITION; SESQUITERPENE; CONSTITUENTS; ANTIOXIDANT;
D O I：
10.3109/13880200903164386
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The GC-MS analysis revealed that the leaf essential oils of Myrciaria tenella (DC.) Berg and Calycorectes sellowianus O. Berg (Myrtaceae) were composed of 34 and 37 compounds, respectively. The main constituents of M. tenella oil were beta-caryophyllene (25.1%), and spathulenol (9.7%), while for C. sellowianus were guaiol (13.1%) and beta-caryophyllene (8.6%). The anti-inflammatory effect of both essential oils was investigated in vitro and in vivo. Both oils reduced significantly (p < 0.005) the treated neutrophils chemotaxis with 93% and 91% inhibition for M. tenella and C. sellowianus, respectively. However, in the systemic treatment with the essential oils (50 mg/kg p.o.) only the M. tenella oil was able to significantly reduce the carrageenan-induced paw edema with a similar effect to that observed for indomethacin (10 mg/kg), the positive control.</.
引用
收藏
页码：433 / 438
页数：6
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