Allogeneic hematopoietic cell transplantation for myelodysplastic syndrome: prognostic significance of pre-transplant IPSS score and comorbidity

被引：29

作者：

Lee, J-H ^{[1
]}

Lim, S-N ^{[1
]}

Kim, D-Y ^{[1
]}

Kim, S. H. ^{[1
]}

Lee, Y-S ^{[1
]}

Kang, Y-A ^{[1
]}

Kang, S-I

Jeon, M. J. ^{[1
]}

Seol, M. ^{[1
]}

Seo, E-J ^{[2
]}

Chi, H. S. ^{[2
]}

Park, C. J. ^{[2
]}

Jang, S. ^{[2
]}

Yun, S-C ^{[3
]}

Lee, K-H ^{[1
]}

机构：

[1] Univ Ulsan, Coll Med, Dept Internal Med, Asan Med Ctr, Seoul 138736, South Korea

[2] Univ Ulsan, Coll Med, Dept Lab Med, Asan Med Ctr, Seoul 138736, South Korea

[3] Univ Ulsan, Coll Med, Dept Prevent Med, Asan Med Ctr, Seoul 138736, South Korea

来源：

BONE MARROW TRANSPLANTATION | 2010年 / 45卷 / 03期

关键词：

MDS; HCT; IPSS; comorbidity; BONE-MARROW-TRANSPLANTATION; ACUTE MYELOID-LEUKEMIA; HLA-IDENTICAL SIBLINGS; VERSUS-HOST DISEASE; REDUCED-INTENSITY; LONG-TERM; CHRONIC GRAFT; INDEX; RISK; OUTCOMES;

D O I：

10.1038/bmt.2009.190

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We analyzed the clinical significance of pre-transplant International Prognostic Scoring System (IPSS) score and comorbidity in 68 patients who underwent allogeneic hematopoietic cell transplantation (HCT) for myelodys-plastic syndrome (MDS) (n-48) or acute myeloid leukemia evolved from MDS (n=20) between December 1995 and January 2008 in a single institute. During a median follow-up period of 41.0 months (range, 3.2-132.0 months), 27 patients died, and 7 relapsed. The 5-year probabilities of overall survival (OS) and event-free survival (EFS) were 60.0 and 57.4%, respectively, and the 5-year cumulative incidences of non-relapse mortality (CINRM) and relapse were 32.7 and 9.9%, respectively. OS, EFS, and CINRM were significantly different according to pre-transplant IPSS score and presence of pre-transplant comorbidity, which were independent risk factors along with Karnofsky performance score in multivariate analyses. In conclusion, pre-transplant IPSS score and comorbidity may stratify the risk of post transplant outcomes in MDS.

引用

页码：450 / 457

页数：8

共 41 条

[1] Impact of conditioning regimen intensity on outcome of allogeneic hematopoietic cell transplantation for advanced acute myelogenous leukemia and myelodyspiastic syndrome [J].

Alyea, Edwin P. ;

Kim, Haesook T. ;

Ho, Vincent ;

Cutler, Corey ;

DeAngelo, Daniel J. ;

Stone, Richard ;

Ritz, Jerome ;

Antin, Joseph H. ;

Soiffer, Robert J. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2006, 12 (10) :1047-1055

[2] Bone marrow transplantation for myelodysplasia [J].

Anderson, JE .

BLOOD REVIEWS, 2000, 14 (02) :63-77

[3]

Anderson JE, 1996, BLOOD, V87, P51

[4] BONE-MARROW TRANSPLANTATION FOR PATIENTS WITH MYELODYSPLASIA - PRETREATMENT VARIABLES AND OUTCOME [J].

APPELBAUM, FR ;

BARRALL, J ;

STORB, R ;

FISHER, LD ;

SCHOCH, G ;

RAMBERG, RE ;

SHULMAN, H ;

ANASETTI, C ;

BEARMAN, SI ;

BEATTY, P ;

BENSINGER, WI ;

BUCKNER, CD ;

CLIFT, RA ;

HANSEN, JA ;

MARTIN, P ;

PETERSEN, FB ;

SANDERS, JE ;

SINGER, J ;

STEWART, P ;

SULLIVAN, KM ;

WITHERSPOON, RP ;

THOMAS, ED .

ANNALS OF INTERNAL MEDICINE, 1990, 112 (08) :590-597

[5]

Appelbaum FR, 1998, LEUKEMIA, V12, pS25

[6] Unrelated bone marrow transplantation in patients with myelodysplastic syndromes and secondary acute myeloid leukemia: an EBMT survey [J].

Arnold, R ;

de Witte, T ;

van Biezen, A ;

Hermans, J ;

Jacobsen, N ;

Runde, V ;

Gratwohl, A ;

Apperley, JF .

BONE MARROW TRANSPLANTATION, 1998, 21 (12) :1213-1216

[7] Allogeneic stem cell transplantation for myelodysplastic syndrome [J].

Barrett, A. John ;

Savani, Bipin N. .

SEMINARS IN HEMATOLOGY, 2008, 45 (01) :49-59

[8]

Bennett JM, 2000, INT J HEMATOL, V72, P131

[9]

BENNETT JM, 1982, BRIT J HAEMATOL, V51, P189, DOI 10.1111/j.1365-2141.1982.tb08475.x

[10] Unrelated donor marrow transplantation for myelodysplastic syndromes: outcome analysis in 510 transplants facilitated by the National Marrow Donor Program [J].

Castro-Malaspina, H ;

Harris, RE ;

Gajewski, J ;

Ramsay, N ;

Collins, R ;

Dharan, B ;

King, R ;

Deeg, HJ .

BLOOD, 2002, 99 (06) :1943-1951

← 1 2 3 4 5 →