Yin and yang of cannabinoid CB1 receptor: CB1 deletion in immune cells causes exacerbation while deletion in non-immune cells attenuates obesity

被引：6

作者：

Miranda, Kathryn ^{[1
]}

Becker, William ^{[1
]}

Busbee, Philip B. ^{[1
]}

Dopkins, Nicholas ^{[1
]}

Abdulla, Osama A. ^{[1
]}

Zhong, Yin ^{[1
]}

Zhang, Jiajia ^{[2
]}

Nagarkatti, Mitzi ^{[1
]}

Nagarkatti, Prakash S. ^{[1
]}

机构：

[1] Univ South Carolina, Dept Pathol Microbiol & Immunol, Sch Med, Columbia, SC 29209 USA

[2] Univ South Carolina, Arnold Sch Publ Hlth, Epidemiol & Biostat, Columbia, SC USA

来源：

ISCIENCE | 2022年 / 25卷 / 09期

关键词：

BROWN ADIPOSE-TISSUE; DIET-INDUCED OBESITY; MACROPHAGE POLARIZATION; MEDIATED REGULATION; INSULIN-RESISTANCE; SUPPRESSOR-CELLS; GUT MICROBIOME; ACTIVATION; MICE; INFLAMMATION;

D O I：

10.1016/j.isci.2022.104994

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

While blockade of cannabinoid receptor 1 (CB1) has been shown to attenuate diet-induced obesity (DIO), its relative role in different cell types has not been tested. The current study investigated the role of CB1 in immune vs non-immune cells during DIO by generating radiation-induced bone marrow chimeric mice that expressed functional CB1 in all cells except the immune cells or expressed CB1 only in immune cells. CB1(-/-) recipient hosts were resistant to DIO, indicating that CB1 in non-immune cells is necessary for induction of DIO. Interestingly, chimeras with CB1(-/-) in immune cells showed exacerbation in DIO combined with infiltration of bone-marrow-derived macrophages to the brain and visceral adipose tissue, elevated food intake, and increased glucose intolerance. These results demonstrate the opposing role of CB1 in hematopoietic versus non-hematopoietic cells during DIO and suggests that targeting immune CB1 receptors provides a new pathway to ameliorate obesity and related metabolic disorders.

引用

页数：15

共 62 条

[51] Protective Role of Cannabinoid Receptor 2 Activation in Galactosamine/Lipopolysaccharide-Induced Acute Liver Failure through Regulation of Macrophage Polarization and MicroRNAs [J].