Relevance of Non-Targeted Effects for Radiotherapy and Diagnostic Radiology; A Historical and Conceptual Analysis of Key Players

被引：17

作者：

Mothersill, Carmel ^{[1
]}

Rusin, Andrej ^{[1
]}

Seymour, Colin ^{[1
]}

机构：

[1] McMaster Univ, Dept Biol, Hamilton, ON L8S 4L8, Canada

来源：

CANCERS | 2019年 / 11卷 / 09期

基金：

加拿大自然科学与工程研究理事会;

关键词：

bystander effect; genomic instability; lethal mutations; radiotherapy; diagnostic radiology; RADIATION-INDUCED BYSTANDER; NF-KAPPA-B; INDUCED GENOMIC INSTABILITY; CELL-CYCLE ARREST; SISTER-CHROMATID EXCHANGES; MINISATELLITE MUTATION-RATE; LOW-DOSE HYPERSENSITIVITY; P53 PROTEIN EXPRESSION; HUMAN EPITHELIAL-CELLS; NITRIC-OXIDE;

D O I：

10.3390/cancers11091236

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Non-targeted effects (NTE) such as bystander effects or genomic instability have been known for many years but their significance for radiotherapy or medical diagnostic radiology are far from clear. Central to the issue are reported differences in the response of normal and tumour tissues to signals from directly irradiated cells. This review will discuss possible mechanisms and implications of these different responses and will then discuss possible new therapeutic avenues suggested by the analysis. Finally, the importance of NTE for diagnostic radiology and nuclear medicine which stems from the dominance of NTE in the low-dose region of the dose-response curve will be presented. Areas such as second cancer induction and microenvironment plasticity will be discussed.

引用

页数：25

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