Reaction of Electrons with DNA: Radiation Damage to Radiosensitization

被引：68

作者：

Kumar, Anil ^{[1
]}

Becker, David ^{[1
]}

Adhikary, Amitava ^{[1
]}

Sevilla, Michael D. ^{[1
]}

机构：

[1] Oakland Univ, Dept Chem, Rochester, MI 48309 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 16期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

quasi-free electron; solvated electron; low energy electrons; ion-beam radiation; radiosensitization; SUGAR-PHOSPHATE BACKBONE; CONDUCTION-BAND EDGE; ION-BEAM IRRADIATION; HYDRATED ELECTRON; SOLVATED ELECTRONS; SPIN-RESONANCE; STRAND BREAKS; ABSORPTION-SPECTRUM; REDOX POTENTIALS; AQUEOUS ELECTRON;

D O I：

10.3390/ijms20163998

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review article provides a concise overview of electron involvement in DNA radiation damage. The review begins with the various states of radiation-produced electrons: Secondary electrons (SE), low energy electrons (LEE), electrons at near zero kinetic energy in water (quasi-free electrons, (e(qf)(-))) electrons in the process of solvation in water (presolvated electrons, e(pre)(-)), and fully solvated electrons (e(aq)(-)). A current summary of the structure of e(aq)(-), and its reactions with DNA-model systems is presented. Theoretical works on reduction potentials of DNA-bases were found to be in agreement with experiments. This review points out the proposed role of LEE-induced frank DNA-strand breaks in ion-beam irradiated DNA. The final section presents radiation-produced electron-mediated site-specific formation of oxidative neutral aminyl radicals from azidonucleosides and the evidence of radiosensitization provided by these aminyl radicals in azidonucleoside-incorporated breast cancer cells.

引用

页数：26

共 132 条

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