Current Therapeutic Options in the Treatment of Rheumatoid Arthritis

被引：154

作者：

Koehler, Birgit M. ^{[1
]}

Guenther, Janine ^{[1
]}

Kaudewitz, Dorothee ^{[1
]}

Lorenz, Hanns-Martin ^{[1
]}

机构：

[1] Univ Hosp Heidelberg, Div Rheumatol, Internal Med 5, D-69120 Heidelberg, Germany

来源：

JOURNAL OF CLINICAL MEDICINE | 2019年 / 8卷 / 07期

关键词：

Rheumatoid Arthritis; therapy; DMARD; MTX; Tumor Necrosis Factor-Alpha Inhibitors; TUMOR-NECROSIS-FACTOR; HEART-FAILURE; DOUBLE-BLIND; SAFETY; METHOTREXATE; ADALIMUMAB; ANAKINRA; EFFICACY; TOFACITINIB; COMBINATION;

D O I：

10.3390/jcm8070938

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of the joints. Untreated RA leads to a destruction of joints through the erosion of cartilage and bone. The loss of physical function is the consequence. Early treatment is important to control disease activity and to prevent joint destruction. Nowadays, different classes of drugs with different modes of action are available to control the inflammation and to achieve remission. In this review, we want to discuss differences and similarities of these different drugs.

引用

页数：15

共 80 条

[41] IL1-blocking therapy in colchicine-resistant familial Mediterranean fever [J].

Koehler, Birgit Maria ;

Lorenz, Hanns-Martin ;

Blank, Norbert .

EUROPEAN JOURNAL OF RHEUMATOLOGY, 2018, 5 (04) :230-234

[42] Effectiveness of anakinra in rheumatic disease in patients naive to biological drugs or previously on TNF blocking drugs:: an observational study [J].

Konttinen, Liisa ;

Kankaanpaa, Eeva ;

Luosujarvi, Riitta ;

Blafield, Harri ;

Vuori, Kaisa ;

Hakala, Markku ;

Rantalaiho, Vappu ;

Savolainen, Elina ;

Uutela, Toini ;

Nordstrom, Dan .

CLINICAL RHEUMATOLOGY, 2006, 25 (06) :882-884

[43] Tofacitinib in Combination With Nonbiologic Disease-Modifying Antirheumatic Drugs in Patients With Active Rheumatoid Arthritis A Randomized Trial [J].

Kremer, Joel ;

Li, Zhan-Guo ;

Hall, Stephen ;

Fleischmann, Roy ;

Genovese, Mark ;

Martin-Mola, Emilio ;

Isaacs, John D. ;

Gruben, David ;

Wallenstein, Gene ;

Krishnaswami, Sriram ;

Zwillich, Samuel H. ;

Koncz, Tamas ;

Riese, Richard ;

Bradley, John .

ANNALS OF INTERNAL MEDICINE, 2013, 159 (04) :253-+

[44]

Krüger K, 2014, Z RHEUMATOL, V73, P77, DOI 10.1007/s00393-013-1301-z

[45] The use of leflunomid in rheumatoid arthritis [J].

Krüger, K ;

Bolten, W .

ZEITSCHRIFT FUR RHEUMATOLOGIE, 2005, 64 (02) :96-101

[46] Case reports of heart failure after therapy with a tumor necrosis factor antagonist [J].

Kwon, HJ ;

Coté, TR ;

Cuffe, MS ;

Kramer, JM ;

Braun, MM .

ANNALS OF INTERNAL MEDICINE, 2003, 138 (10) :807-811

[47] The efficacy and safety of rituximab for the treatment of active rheumatoid arthritis: a systematic review and meta-analysis of randomized controlled trials [J].

Lee, Young Ho ;

Bae, Sang-Cheol ;

Song, Gwan Gyu .

RHEUMATOLOGY INTERNATIONAL, 2011, 31 (11) :1493-1499

[48] Placental Transfer of Anti-Tumor Necrosis Factor Agents in Pregnant Patients With Inflammatory Bowel Disease [J].

Mahadevan, Uma ;

Wolf, Douglas C. ;

Dubinsky, Marla ;

Cortot, Antoine ;

Lee, Scott D. ;

Siegel, Corey A. ;

Ullman, Thomas ;

Glover, Sarah ;

Valentine, John F. ;

Rubin, David T. ;

Miller, Jocelyn ;

Abreu, Maria T. .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2013, 11 (03) :286-292

[49] MATERNAL-FETAL TRANSPORT OF IMMUNOGLOBULIN-G AND ITS SUBCLASSES DURING THE 3RD TRIMESTER OF HUMAN-PREGNANCY [J].

MALEK, A ;

SAGER, R ;

SCHNEIDER, H .

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 1994, 32 (01) :8-14

[50] Tumor necrosis factor-α inhibitor therapy and fetal risk: A systematic literature review [J].

Marchioni, Renee M. ;

Lichtenstein, Gary R. .

WORLD JOURNAL OF GASTROENTEROLOGY, 2013, 19 (17) :2591-2602

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