Current Therapeutic Options in the Treatment of Rheumatoid Arthritis

被引：154

作者：

Koehler, Birgit M. ^{[1
]}

Guenther, Janine ^{[1
]}

Kaudewitz, Dorothee ^{[1
]}

Lorenz, Hanns-Martin ^{[1
]}

机构：

[1] Univ Hosp Heidelberg, Div Rheumatol, Internal Med 5, D-69120 Heidelberg, Germany

来源：

JOURNAL OF CLINICAL MEDICINE | 2019年 / 8卷 / 07期

关键词：

Rheumatoid Arthritis; therapy; DMARD; MTX; Tumor Necrosis Factor-Alpha Inhibitors; TUMOR-NECROSIS-FACTOR; HEART-FAILURE; DOUBLE-BLIND; SAFETY; METHOTREXATE; ADALIMUMAB; ANAKINRA; EFFICACY; TOFACITINIB; COMBINATION;

D O I：

10.3390/jcm8070938

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of the joints. Untreated RA leads to a destruction of joints through the erosion of cartilage and bone. The loss of physical function is the consequence. Early treatment is important to control disease activity and to prevent joint destruction. Nowadays, different classes of drugs with different modes of action are available to control the inflammation and to achieve remission. In this review, we want to discuss differences and similarities of these different drugs.

引用

页数：15

共 80 条

[1] Diagnosis and Management of Rheumatoid Arthritis A Review [J].

Aletaha, Daniel ;

Smolen, Josef S. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2018, 320 (13) :1360-1372

[2]

[Anonymous], MAJOR SIDE EFFECTS L

[3] Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream [J].

Arkin, MR ;

Wells, JA .

NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (04) :301-317

[4] Long-term safety of abatacept in patients with rheumatoid arthritis [J].

Atzeni, Fabiola ;

Sarzi-Puttini, Piercarlo ;

Mutti, Alessandra ;

Bugatti, Serena ;

Cavagna, Lorenzo ;

Caporali, Roberto .

AUTOIMMUNITY REVIEWS, 2013, 12 (12) :1115-1117

[5]

Box SA, 1997, BRIT J RHEUMATOL, V36, P382

[6] Leflunomide: mode of action in the treatment of rheumatoid arthritis [J].

Breedveld, FC ;

Dayer, JM .

ANNALS OF THE RHEUMATIC DISEASES, 2000, 59 (11) :841-849

[7] Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers [J].

Brown, Philip M. ;

Pratt, Arthur G. ;

Isaacs, John D. .

NATURE REVIEWS RHEUMATOLOGY, 2016, 12 (12) :731-742

[8] Efficacy and safety of sarilumab monotherapy versus adalimumab monotherapy for the treatment of patients with active rheumatoid arthritis (MONARCH): a randomised, double-blind, parallel-group phase III trial [J].

Burmester, Gerd R. ;

Lin, Yong ;

Patel, Rahul ;

van Adelsberg, Janet ;

Mangan, Erin K. ;

Graham, Neil M. H. ;

van Hoogstraten, Hubert ;

Bauer, Deborah ;

Ignacio Vargas, Juan ;

Lee, Eun Bong .

ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 (05) :840-847

[9] The 2015 American College of Rheumatology guideline for the treatment of rheumatoid arthritis should include new standards for hepatitis B screening: comment on the article by Singh et al [J].

Calabrese, Leonard H. ;

Calabrese, Cassandra ;

Kirchner, Elizabeth .

ARTHRITIS CARE & RESEARCH, 2016, 68 (05) :723-724

[10] Pregnancy outcomes after maternal exposure to rituximab [J].

Chakravarty, Eliza F. ;

Murray, Elaine R. ;

Kelman, Ariella ;

Farmer, Pamela .

BLOOD, 2011, 117 (05) :1499-1506

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