Disseminated Mycobacterium avium Complex Myositis in a Patient With Graft-Versus-Host Disease

被引：4

作者：

Kompa, Kathryn Grace ^{[1
]}

Trottier, Caitlin A. ^{[2
]}

Hyman, Charles L. ^{[3
]}

Kohli, Rakhi ^{[2
]}

机构：

[1] Tufts Univ, Sch Med, Boston, MA 02111 USA

[2] Tufts Med Ctr, Div Geog Med & Infect Dis, Box 41,800 Washington St, Boston, MA 02111 USA

[3] Bassett Med Ctr, Cooperstown, NY USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2022年 / 9卷 / 08期

关键词：

disseminated MAC; immunocompromise; ruxolitinib; myositis; HEMATOPOIETIC STEM-CELL; PYOMYOSITIS; INFECTIONS; INTRACELLULARE;

D O I：

10.1093/ofid/ofac385

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mycobacterium avium complex (MAC) is a ubiquitous environmental pathogen that was infrequently reported as a cause of disease before the human immunodeficiency virus (HIV)/acquired immune deficiency syndrome epidemic. We present a case of MAC pyomyositis and bacteremia in a 59-year-old man with chronic lymphocytic leukemia in remission after an allogenic stem cell transplant. His posttransplant course was complicated by graft-versus-host disease, requiring treatment with oral steroids and ruxolitinib. In this report, we review the literature on disseminated MAC infection in patients with and without HIV. We also propose a potential mechanism by which this patient may have developed disseminated disease. Disseminated MAC myositis is uncommon in persons without HIV and requires a high index of suspicion for timely diagnosis.

引用

页数：4

共 25 条

[1] Mycobacterial Infections With Ruxolitinib: A Retrospective Pharmacovigilance Review [J].