Disturbed temporal dynamics of episodic retrieval activity with preserved spatial activity pattern in amnestic mild cognitive impairment: A simultaneous EEG-fMRI study

被引:9
作者
Shu, Hao [1 ]
Gu, Lihua [1 ]
Yang, Ping [4 ]
Lucas, Molly, V [6 ,7 ,8 ,9 ]
Gao, Lijuan [1 ]
Zhang, Hongxing [3 ]
Zhang, Haisan [3 ]
Xu, Zhan [10 ]
Wu, Wei [5 ,6 ,7 ,8 ,9 ]
Li, Ling [2 ]
Zhang, Zhijun [1 ,2 ,3 ]
机构
[1] Southeast Univ, Affiliated ZhongDa Hosp, Sch Med, Dept Neurol,Neuropsychiat Inst,Key Lab Dev Genes, Nanjing 210009, Jiangsu, Peoples R China
[2] Univ Elect Sci & Technol China, Ctr Informat Med, Sch Life Sci & Technol, Key Lab Neurolnformat,Minist Educ,High Field Magn, Chengdu 610054, Peoples R China
[3] Xingxiang Med Univ, Dept Psychiat, Affiliated Hosp 2, Xinxiang 453002, Henan, Peoples R China
[4] South China Normal Univ, Inst Brain Res & Rehabil, Guangzhou 510631, Peoples R China
[5] South China Univ Technol, Sch Automat Sci & Engn, Guangzhou 510640, Peoples R China
[6] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
[7] Stanford Univ, Wu Tsai Neurosci Inst, Stanford, CA 94305 USA
[8] Vet Affairs Palo Alto Healthcare Syst, Palo Alto, CA 94394 USA
[9] Sierra Pacific Mental Illness Res Educ & Clin Ctr, Palo Alto, CA 94394 USA
[10] Univ Texas MD Anderson Canc Ctr, Imaging Phys, 1515 Holcombe Blvd, Houston, TX 77030 USA
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
Amnestic mild cognitive impairment; Episodic memory; Familiarity; Recollection; Retrieval; Simultaneous EEG-fMRI; ALZHEIMERS-DISEASE; PARIETAL CORTEX; OLDER-ADULTS; MEMORY; RECOLLECTION; ERP; FAMILIARITY;
D O I
10.1016/j.nicl.2021.102572
中图分类号
R445 [影像诊断学];
学科分类号
100207 ;
摘要
Episodic memory (EM) deficit is the core cognitive dysfunction of amnestic mild cognitive impairment (aMCI). However, the episodic retrieval pattern detected by functional MRI (fMRI) appears preserved in aMCI subjects. To address this discrepancy, simultaneous electroencephalography (EEG)-fMRI recording was employed to determine whether temporal dynamics of brain episodic retrieval activity were disturbed in patients with aMCI. Twenty-six aMCI and 29 healthy control (HC) subjects completed a word-list memory retrieval task during simultaneous EEG-fMRI. The retrieval success activation pattern was detected with fMRI analysis, and the familiarity- and recollection-related components of episodic retrieval activity were identified using event-related potential (ERP) analysis. The fMRI-constrained ERP analysis explored the temporal dynamics of brain activity in the retrieval success pattern, and the ERP-informed fMRI analysis detected fMRI correlates of the ERP components related to familiarity and recollection processes. The two groups exhibited similar retrieval success patterns in the bilateral posteromedial parietal cortex, the left inferior parietal lobule (IPL), and the left lateral prefrontal cortex (LPFC). The fMRI-constrained ERP analysis showed that the aMCI group did not exhibit old/ new effects in the IPL and LPFC that were observed in the HC group. In addition, the aMCI group showed disturbed fMRI correlate of ERP recollection component that was associated with inferior EM performance. Therefore, in this study, we identified disturbed temporal dynamics in episodic retrieval activity with a preserved spatial activity pattern in aMCI. Taken together, the simultaneous EEG-fMRI technique demonstrated the potential to identify individuals with a high risk of cognitive deterioration.
引用
收藏
页数:9
相关论文
共 36 条
[1]   Identification of EEG events in the MR scanner: The problem of pulse artifact and a method for its subtraction [J].
Allen, PJ ;
Polizzi, G ;
Krakow, K ;
Fish, DR ;
Lemieux, L .
NEUROIMAGE, 1998, 8 (03) :229-239
[2]   Using Pictures and Words To Understand Recognition Memory Deterioration in Amnestic Mild Cognitive Impairment and Alzheimer's Disease: A Review [J].
Ally, Brandon A. .
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, 2012, 12 (06) :687-694
[3]   Protective role of educational level on episodic memory aging: An event-related potential study [J].
Angel, Lucie ;
Fay, Severine ;
Bouazzaoui, Badiaa ;
Baudouin, Alexia ;
Isingrini, Michel .
BRAIN AND COGNITION, 2010, 74 (03) :312-323
[4]   Neural correlates of cued recall in young and older adults: an event-related potential study [J].
Angel, Lucie ;
Fay, Severine ;
Bouazzaoui, Badiaa ;
Granjon, Lionel ;
Isingrini, Michel .
NEUROREPORT, 2009, 20 (01) :75-79
[5]   Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease [J].
Brier, Matthew R. ;
Gordon, Brian ;
Friedrichsen, Karl ;
McCarthy, John ;
Stern, Ari ;
Christensen, Jon ;
Owen, Christopher ;
Aldea, Patricia ;
Su, Yi ;
Hassenstab, Jason ;
Cairns, Nigel J. ;
Holtzman, David M. ;
Fagan, Anne M. ;
Morris, John C. ;
Benzinger, Tammie L. S. ;
Ances, Beau M. .
SCIENCE TRANSLATIONAL MEDICINE, 2016, 8 (338)
[6]   Top-down and bottom-up attention-to-memory: Mapping functional connectivity in two distinct networks that underlie cued and uncued recognition memory [J].
Burianova, Liana ;
Ciaramelli, Elisa ;
Grady, Cheryl L. ;
Moscovitch, Morris .
NEUROIMAGE, 2012, 63 (03) :1343-1352
[7]   The parietal cortex and episodic memory: an attentional account [J].
Cabeza, Roberto ;
Ciaramelli, Elisa ;
Olson, Ingrid R. ;
Moscovitch, Morris .
NATURE REVIEWS NEUROSCIENCE, 2008, 9 (08) :613-625
[8]   Top-Down and Bottom-Up Attention to Memory Are Dissociated in Posterior Parietal Cortex: Neuroimaging and Neuropsychological Evidence [J].
Ciaramelli, Elisa ;
Grady, Cheryl ;
Levine, Brian ;
Ween, Jon ;
Moscovitch, Morris .
JOURNAL OF NEUROSCIENCE, 2010, 30 (14) :4943-4956
[9]   Functional neuroanatomy of the encoding and retrieval processes of verbal episodic memory in MCI [J].
Clement, Francis ;
Belleville, Sylvie ;
Mellah, Samira .
CORTEX, 2010, 46 (08) :1005-1015
[10]   The Episodic Memory System: Neurocircuitry and Disorders [J].
Dickerson, Bradford C. ;
Eichenbaum, Howard .
NEUROPSYCHOPHARMACOLOGY, 2010, 35 (01) :86-104