Evolutionary Events Associated with an Outbreak of Meningococcal Disease in Men Who Have Sex with Men

被引：68

作者：

Taha, Muhamed-Kheir ^{[1
,2
]}

Claus, Heike ^{[3
]}

Lappann, Martin ^{[3
]}

Veyrier, Frederic J. ^{[1
,2
,8
]}

Otto, Andreas ^{[4
]}

Becher, Dorte ^{[4
]}

Deghmane, Ala-Eddine ^{[1
,2
]}

Frosch, Matthias ^{[3
]}

Hellenbrand, Wiebke ^{[5
]}

Hong, Eva ^{[1
,2
]}

du Chatelet, Isabelle Parent ^{[6
]}

Prior, Karola ^{[7
]}

Harmsen, Dag ^{[7
]}

Vogel, Ulrich ^{[3
]}

机构：

[1] Inst Pasteur, Invas Bacterial Infect Unit, Paris, France

[2] Natl Reference Ctr Meningococci, Paris, France

[3] Univ Wurzburg, Inst Hyg & Microbiol, Reference Lab Meningococci & Haemophilus Influenz, D-97070 Wurzburg, Germany

[4] Univ Greifswald, Dept Microbial Prote & Mass Spectrometry, Greifswald, Germany

[5] Robert Koch Inst, Immunizat Unit, Berlin, Germany

[6] Inst Veille Sanit, St Maurice, France

[7] Univ Munster, Dept Periodontol, D-48149 Munster, Germany

[8] Univ Quebec, INRS Inst Armand Frappier Inst Natl Rech Sci, Quebec City, PQ, Canada

来源：

PLOS ONE | 2016年 / 11卷 / 05期

基金：

英国惠康基金;

关键词：

NEISSERIA-MENINGITIDIS; SEQUENCE; COMPLEMENT; DIVERSITY; PROTEINS; DATABASE; BINDING; ANIA;

D O I：

10.1371/journal.pone.0154047

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Meningococci spread via respiratory droplets, whereas the closely related gonococci are transmitted sexually. Several outbreaks of invasive meningococcal disease have been reported in Europe and the United States among men who have sex with men (MSM). We recently identified an outbreak of serogroup C meningococcal disease among MSM in Germany and France. In this study, genomic and proteomic techniques were used to analyze the outbreak isolates. In addition, genetically identical urethritis isolates were recovered from France and Germany and included in the analysis. Genome sequencing revealed that the isolates from the outbreak among MSM and from urethritis cases belonged to a clade within clonal complex 11. Proteome analysis showed they expressed nitrite reductase, enabling anaerobic growth as previously described for gonococci. Invasive isolates from MSM, but not urethritis isolates, further expressed functional human factor H binding protein associated with enhanced survival in a newly developed transgenic mouse model expressing human factor H, a complement regulatory protein. In conclusion, our data suggest that urethritis and outbreak isolates followed a joint adaptation route including adaption to the urogenital tract.

引用

页数：11

共 43 条

[41] Enhanced Bacteremia in Human Factor H Transgenic Rats Infected by Neisseria meningitidis [J].