Host monitoring of quorum sensing during Pseudomonas aeruginosa infection

被引：134

作者：

Moura-Alves, Pedro ^{[1
,2
]}

Puyskens, Andreas ^{[1
]}

Stinn, Anne ^{[1
,3
,4
,5
]}

Klemm, Marion ^{[1
]}

Guhlich-Bornhof, Ute ^{[1
]}

Dorhoi, Anca ^{[1
,6
,7
]}

Furkert, Jens ^{[8
]}

Kreuchwig, Annika ^{[8
]}

Protze, Jonas ^{[8
]}

Lozza, Laura ^{[1
,9
]}

Pei, Gang ^{[1
]}

Saikali, Philippe ^{[1
]}

Perdomo, Carolina ^{[1
]}

Mollenkopf, Hans J. ^{[10
]}

Hurwitz, Robert ^{[11
]}

Kirschhoefer, Frank ^{[12
]}

Brenner-Weiss, Gerald ^{[11
]}

Weiner, January, III ^{[1
,14
]}

Oschkinat, Hartmut ^{[8
]}

Kolbe, Michael ^{[3
,4
,5
]}

Krause, Gerd ^{[8
]}

Kaufmann, Stefan H. E. ^{[1
,13
]}

机构：

[1] Max Planck Inst Infect Biol, Dept Immunol, D-10117 Berlin, Germany

[2] Univ Oxford, Ludwig Inst Canc Res, Nuffield Dept Clin Med, Oxford OX3 7DQ, England

[3] Max Planck Inst Infect Biol, Struct Syst Biol, D-10117 Berlin, Germany

[4] Helmholtz Ctr Infect Res HZI, Dept Struct Infect Biol, Ctr Struct Syst Biol, D-22607 Hamburg, Germany

[5] Univ Hamburg, Fac Math Informat & Nat Sci, D-20148 Hamburg, Germany

[6] Friedrich Loeffler Inst, Inst Immunol, Greifswald, Germany

[7] Ernst Moritz Arndt Univ Greifswald, Fac Math & Nat Sci, Greifswald, Germany

[8] Leibniz Forsch Inst Mol Pharmakol FMP, D-13125 Berlin, Germany

[9] Epiontis GmbH Precis Med, D-12489 Berlin, Germany

[10] Max Planck Inst Infect Biol, Dept Immunol, Microarray Core Facil, D-10117 Berlin, Germany

[11] Max Planck Inst Infect Biol, Prot Purificat Core Facil, D-10117 Berlin, Germany

[12] Karlsruhe Inst Technol, Inst Funct Interfaces, Karlsruhe, Germany

[13] Texas A&M Univ, Hagler Inst Adv Study, College Stn, TX 77843 USA

[14] Berlin Inst Hlth, Core Unit Bioinformat, D-10117 Berlin, Germany

来源：

SCIENCE | 2019年 / 366卷 / 6472期

基金：

芬兰科学院; 欧洲研究理事会;

关键词：

ARYL-HYDROCARBON RECEPTOR; N-3-OXODODECANOYL HOMOSERINE LACTONE; LIGAND BINDING DOMAIN; NF-KAPPA-B; EXPRESSION; MODEL; COMMUNICATION; MOLECULES; ZEBRAFISH; RESPONSES;

D O I：

10.1126/science.aaw1629

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Pseudomonas aeruginosa rapidly adapts to altered conditions by quorum sensing (QS), a communication system that it uses to collectively modify its behavior through the production, release, and detection of signaling molecules. QS molecules can also be sensed by hosts, although the respective receptors and signaling pathways are poorly understood. We describe a pattern of regulation in the host by the aryl hydrocarbon receptor (AhR) that is critically dependent on qualitative and quantitative sensing of P. aeruginosa quorum. QS molecules bind to AhR and distinctly modulate its activity. This is mirrored upon infection with P. aeruginosa collected from diverse growth stages and with QS mutants. We propose that by spying on bacterial quorum, AhR acts as a major sensor of infection dynamics, capable of orchestrating host defense according to the status quo of infection.

引用

页码：1472 / +

页数：104

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