SYNTHESIS AND ANTIMICROBIAL PROPERTIES OF SOME THIAZOLE AND PYRIDINE DERIVATIVES

被引:0
作者
Naghiyev, Farid N. [1 ]
Asgarova, Ayten R. [1 ]
Maharramov, Abel M. [1 ]
Rahimova, Almaz G. [1 ]
Akhundova, Mushkinaz A. [1 ]
Mamedov, Ibrahim G. [1 ]
机构
[1] Baku State Univ, Dept Organ Chem, Z Khalilov 23, AZ-1148 Baku, Azerbaijan
来源
NEW MATERIALS COMPOUNDS AND APPLICATIONS | 2020年 / 4卷 / 01期
关键词
thiosemicarbazone; phenacyl bromide; thiazole; iminopyridine; NMR;
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
It was confirmed, that by condensation of thiosemicarbazide derivative of camphor with phenacyl bromide in ethanol and at the presence of piperidine, the corresponding thiazole derivatives are formed. By the interaction of camphor's thiosemicarbazide derivative with methyl ester of alpha-bromoacetic acid in the same reaction conditions, the corresponding thiazolidone derivative was synthesized. The way of synthesis of benzylamine the iminopyridine derivative by the one-pot three-component reaction of p-bromobenzylidene malononitrile with malononitrile has been developed. Synthesized pyridine derivative demonstrates high antimicrobial activity. Structures of all synthesized compounds confirmed by NMR spectroscopy.
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页码:5 / 9
页数:5
相关论文
共 16 条
[1]   Synthesis, characterization and antibacterial activity of some new thiazole and thiazolidinone derivatives containing phenyl benzoate moiety [J].
Abdel-Galil, Ebrahim ;
Moawad, Evelin B. ;
El-Mekabaty, Ahmed ;
Said, Gehad E. .
SYNTHETIC COMMUNICATIONS, 2018, 48 (16) :2083-2092
[2]   Synthesis and characterization of 2-(4-aryl-3-cyano-6-methylpyridin-2(1H)-ylidene)malononitriles [J].
Bardasov, Ivan N. ;
Alekseeva, Anastasiya U. ;
Chunikhin, Sergey S. ;
Shishlikova, Maria A. ;
Ershov, Oleg, V .
TETRAHEDRON LETTERS, 2019, 60 (17) :1170-1173
[3]   Synthesis, antimicrobial activity, and determination of the lipophilicity of ((cyclohex-3-enylmethylene)hydrazinyl)thiazole derivatives [J].
Biernasiuk, Anna ;
Kawczynska, Magdalena ;
Berecka-Rycerz, Anna ;
Rosada, Beata ;
Gumieniczek, Anna ;
Malm, Anna ;
Dzitko, Katarzyna ;
Laczkowski, Krzysztof Z. .
MEDICINAL CHEMISTRY RESEARCH, 2019, 28 (11) :2023-2036
[4]   Synthesis, structures, antimicrobial activity and biosafety evaluation of pyridine-2-formaldehyde-N-susbtituted-thiosemicarbazonates of copper(II) [J].
Kaushal, Mani ;
Lobana, Tarlok S. ;
Nim, Lovedeep ;
Kaur, Jaskamal ;
Bala, Ritu ;
Hundal, Geeta ;
Arora, Daljit S. ;
Garcia-Santos, Isabel ;
Duff, Courtney E. ;
Jasinski, Jerry P. .
NEW JOURNAL OF CHEMISTRY, 2018, 42 (19) :15879-15894
[5]   Synthesis and antibacterial activity of some new thiazole and thiophene derivatives [J].
Khalil, A. M. ;
Berghot, M. A. ;
Gouda, M. A. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (11) :4434-4440
[6]   A facile strategy for the one pot multicomponent synthesis of spiro dihydropyridines from amines and activated alkynes [J].
Kiruthika, Selvarangam E. ;
Lakshmi, Neelakandan Vidhya ;
Banu, Babu Rasidha ;
Perumal, Paramasivan T. .
TETRAHEDRON LETTERS, 2011, 52 (48) :6508-6511
[7]   Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation [J].
Liaras, K. ;
Geronikaki, A. ;
Glamoclija, J. ;
Ciric, A. ;
Sokovic, M. .
BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (10) :3135-3140
[8]   Synthesis of Spiroindolines on the Basis of Isatylidene Malononitrile [J].
Magerramov, A. M. ;
Naghiyev, F. N. ;
Mamedova, G. Z. ;
Asadov, Kh. A. ;
Mamedov, I. G. .
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2018, 54 (11) :1731-1734
[9]  
Mamedov IG, 2017, INDIAN J CHEM B, V56, P192
[10]   Efficient synthesis of new tricyclic pyrano[3,2-c]pyridine derivatives [J].
Mamedov, Ibrahim G. ;
Khrustalev, Victor N. ;
Dorovatovskii, Pavel V. ;
Naghiev, Farid N. ;
Maharramov, Abel M. .
MENDELEEV COMMUNICATIONS, 2019, 29 (02) :232-233