Inhibition of DNA topoisomerase I by cryptotanshinone from Salvia miltiorrhiza

被引：0

作者：

Lee, DS ^{[1
]}

Hong, SD ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Coll Nat Sci, Dept Microbiol, Taegu 702701, South Korea

来源：

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 1998年 / 8卷 / 01期

关键词：

cryptotanshinone; inhibitor of DNA topoisomerase I;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cryptotanshinone induced topoisomerase I-mediated DNA cleavage in vitro as strongly as camptothecin, whereas topoisomerase II-mediated DNA cleavage was not induced by this agent. In DNA relaxation assay using calf thymus DNA topoisomerase I and supercoiled pBR322 DNA, cryptotanshinone inhibited topoisomerase I-mediated DNA relaxation in a dose-dependent manner. In unwinding assay, cryptotanshinone (50 mu M) did not shift the topoisomers of DNA. These results suggest that cryptotanshinone exerted a preferential inhibition of topoisomerase I without intercalating into DNA.

引用

页码：89 / 91

页数：3

共 47 条

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