Inhibition of DNA topoisomerase I by cryptotanshinone from Salvia miltiorrhiza

被引：0
作者：
Lee, DS [1 ]
Hong, SD [1 ]
机构：
[1] Kyungpook Natl Univ, Coll Nat Sci, Dept Microbiol, Taegu 702701, South Korea
来源：
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 1998年 / 8卷 / 01期
关键词：
cryptotanshinone; inhibitor of DNA topoisomerase I;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Cryptotanshinone induced topoisomerase I-mediated DNA cleavage in vitro as strongly as camptothecin, whereas topoisomerase II-mediated DNA cleavage was not induced by this agent. In DNA relaxation assay using calf thymus DNA topoisomerase I and supercoiled pBR322 DNA, cryptotanshinone inhibited topoisomerase I-mediated DNA relaxation in a dose-dependent manner. In unwinding assay, cryptotanshinone (50 mu M) did not shift the topoisomers of DNA. These results suggest that cryptotanshinone exerted a preferential inhibition of topoisomerase I without intercalating into DNA.
引用
收藏
页码：89 / 91
页数：3
相关论文
共 47 条
[21]   Cryptotanshinone from Salvia miltiorrhiza Bunge (Danshen) inhibited inflammatory responses via TLR4/MyD88 signaling pathway [J].
Li, Xin-Xing ;
Zheng, Xiaoting ;
Liu, Zhenjie ;
Xu, Qiongming ;
Tang, Hongzhen ;
Feng, Jianfang ;
Yang, Shilin ;
Vong, Chi Teng ;
Gao, Hongwei ;
Wang, Yitao .
CHINESE MEDICINE, 2020, 15 (01)
[22]   Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates β-amyloid deposition through upregulating α-secretase in vivo and in vitro [J].
Mei, Zhengrong ;
Zhang, Fangyan ;
Tao, Liang ;
Zheng, Wenhua ;
Cao, Yingnan ;
Wang, Zhaohe ;
Tang, Shu ;
Le, Kang ;
Chen, Shaorui ;
Pi, Rongbiao ;
Liu, Peiqing .
NEUROSCIENCE LETTERS, 2009, 452 (02) :90-95
[23]   Cryptotanshinone from Salvia miltiorrhiza Bunge (Danshen) inhibited inflammatory responses via TLR4/MyD88 signaling pathway [J].
Xin-Xing Li ;
Xiaoting Zheng ;
Zhenjie Liu ;
Qiongming Xu ;
Hongzhen Tang ;
Jianfang Feng ;
Shilin Yang ;
Chi Teng Vong ;
Hongwei Gao ;
Yitao Wang .
Chinese Medicine, 15
[24]   Effects of methyl jasmonate and salicylic acid on cell growth and cryptotanshinone formation in Ti transformed Salvia miltiorrhiza cell suspension cultures [J].
Hui Chen ;
Feng Chen .
Biotechnology Letters, 1999, 21 :803-807
[25]   Effects of methyl jasmonate and salicylic acid on cell growth and cryptotanshinone formation in Ti transformed Salvia miltiorrhiza cell suspension cultures [J].
Chen, H ;
Chen, F .
BIOTECHNOLOGY LETTERS, 1999, 21 (09) :803-807
[26]   Reversal of P-glycoprotein (P-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of Salvia miltiorrhiza [J].
Hu, Tao ;
To, Kenneth K. W. ;
Wang, Lin ;
Zhang, Lin ;
Lu, Lan ;
Shen, Jing ;
Chan, Ruby L. Y. ;
Li, Mingxing ;
Yeung, John H. K. ;
Cho, Chi Hin .
PHYTOMEDICINE, 2014, 21 (11) :1264-1272
[27]   Inhibition of warfarin hydroxylation by major tanshinones of Danshen (Salvia miltiorrhiza) in the rat in vitro and in vivo [J].
Wu, Windy W. P. ;
Yeung, John H. K. .
PHYTOMEDICINE, 2010, 17 (3-4) :219-226
[28]   Cryptotanshinone from the Salvia miltiorrhiza Bunge Attenuates Ethanol-Induced Liver Injury by Activation of AMPK/SIRT1 and Nrf2 Signaling Pathways [J].
Nagappan, Arulkumar ;
Kim, Ji-Hyun ;
Jung, Dae Young ;
Jung, Myeong Ho .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (01)
[29]   Simultaneous determination of tanshinone I, dihydrotanshinone I, tanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography-tandem mass spectrometry:: application to a pharmacokinetic study of a standardized fraction of Salvia miltiorrhiza, PF2401-SF [J].
Park, Eun Jeong ;
Ji, Hye Young ;
Kim, Nam Jin ;
Song, Won Young ;
Kim, Young Hoon ;
Kim, Youn-Chul ;
Sohn, Dong Hwan ;
Lee, Hye Suk .
BIOMEDICAL CHROMATOGRAPHY, 2008, 22 (05) :548-555
[30]   Cryptotanshinone from Salvia miltiorrhiza Roots Reduces Cytokeratin CK1/10 Expression in Keratinocytes by Activation of Peptidyl-prolyl-cis-trans-isomerase FKBP1A [J].
Esch, Stefan ;
Koenig, Simone ;
Bopp, Bertan ;
Jose, Joachim ;
Brandt, Simone ;
Hensel, Andreas .
PLANTA MEDICA, 2019, 85 (07) :552-562
12345